@article{808b2ccf5b8d468d89c71a4b4038fc2a,
title = "Longitudinal Analysis Reveals Early Development of Three MPER-Directed Neutralizing Antibody Lineages from an HIV-1-Infected Individual",
abstract = "Despite extensive structural work, little is known about how MPER-specific HIV antibodies develop. Krebs et al. describe the initiation and early development of three MPER-directed HIV broadly neutralizing antibody lineages from a single donor of the RV217 cohort. One of the antibody lineages appears particularly promising for vaccine design, as it achieved high neutralizing breadth with low mutation from germline.",
keywords = "HIV envelope, neutralizing antibody, next-generation sequencing",
author = "Krebs, {Shelly J.} and Kwon, {Young D.} and Schramm, {Chaim A.} and Law, {William H.} and Gina Donofrio and Zhou, {Kenneth H.} and Syna Gift and Vincent Dussupt and Georgiev, {Ivelin S.} and Sebastian Sch{\"a}tzle and McDaniel, {Jonathan R.} and Lai, {Yen Ting} and Mallika Sastry and Baoshan Zhang and Jarosinski, {Marissa C.} and Amy Ransier and Chenine, {Agnes L.} and Mangaiarkarasi Asokan and Bailer, {Robert T.} and Meera Bose and Alberto Cagigi and Cale, {Evan M.} and Chuang, {Gwo Yu} and Samuel Darko and Driscoll, {Jefferson I.} and Aliaksandr Druz and Jason Gorman and Farida Laboune and Louder, {Mark K.} and Krisha McKee and Letzibeth Mendez and Moody, {M. Anthony} and O'Sullivan, {Anne Marie} and Christopher Owen and Dongjun Peng and Reda Rawi and Eric Sanders-Buell and Shen, {Chen Hsiang} and Shiakolas, {Andrea R.} and Tyler Stephens and Yaroslav Tsybovsky and Courtney Tucker and Raffaello Verardi and Keyun Wang and Jing Zhou and Tongqing Zhou and George Georgiou and Alam, {S. Munir} and Haynes, {Barton F.} and Morgane Rolland and Matyas, {Gary R.} and Polonis, {Victoria R.} and McDermott, {Adrian B.} and Douek, {Daniel C.} and Lawrence Shapiro and Sodsai Tovanabutra and Michael, {Nelson L.} and Mascola, {John R.} and Robb, {Merlin L.} and Kwong, {Peter D.} and Doria-Rose, {Nicole A.}",
note = "Funding Information: We thank T. Gurley, E. Viox, L. Armand, and the MHRP Viral Sequencing Core for technical contributions; J. Stuckey for assistance with graphics; and M. Zwick and members of the Structural Biology Section and the Structural Bioinformatics Core Section of the Vaccine Research Center for helpful comments. We thank J. Baalwa, D. Ellenberger, F. Gao, B. Hahn, K. Hong, J. Kim, F. McCutchan, D. Montefiori, L. Moris, J. Overbaugh, E. Sanders-Buell, G. Shae, R. Swanstrom, M. Thomson, S. Tovanabutra, C. Williamson, and L. Zhang for contributing HIV-1 Env plasmids for our neutralization panel. This work was supported by cooperative agreements (W81XWH-07-2-0067, W81XWH-11-2-0174, and W81XWH-18-2-0040) between The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. and the U.S. Department of Defense (DOD), United States; R01 AI131722 to I.S.G.; Leidos Biomedical Research Inc. contract 15X219 and DTRA contract HDTRA1-12-C-0105 to G.G.; Frederick National Laboratory for Cancer Research contract #HHSN261200800001E to Y.T. and T.S.; and the Intramural Research Program of the Vaccine Research Center, NIAID, National Institutes of Health, United States. The investigators have adhered to the policies for protection of human subjects as prescribed in AR 70–25. Use of insertion device 22 (SER-CAT) at the Advanced Photon Source was supported by the United States Department of Energy, Basic Energy Sciences, Office of Science, under contract W-31-109-Eng-38. Funding Information: We thank T. Gurley, E. Viox, L. Armand, and the MHRP Viral Sequencing Core for technical contributions; J. Stuckey for assistance with graphics; and M. Zwick and members of the Structural Biology Section and the Structural Bioinformatics Core Section of the Vaccine Research Center for helpful comments. We thank J. Baalwa, D. Ellenberger, F. Gao, B. Hahn, K. Hong, J. Kim, F. McCutchan, D. Montefiori, L. Moris, J. Overbaugh, E. Sanders-Buell, G. Shae, R. Swanstrom, M. Thomson, S. Tovanabutra, C. Williamson, and L. Zhang for contributing HIV-1 Env plasmids for our neutralization panel. This work was supported by cooperative agreements ( W81XWH-07-2-0067 , W81XWH-11-2-0174 , and W81XWH-18-2-0040 ) between The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. and the U.S. Department of Defense (DOD), United States; R01 AI131722 to I.S.G.; Leidos Biomedical Research Inc . contract 15X219 and DTRA contract HDTRA1-12-C-0105 to G.G.; Frederick National Laboratory for Cancer Research contract #HHSN261200800001E to Y.T. and T.S.; and the Intramural Research Program of the Vaccine Research Center, NIAID, National Institutes of Health , United States. The investigators have adhered to the policies for protection of human subjects as prescribed in AR 70–25. Use of insertion device 22 (SER-CAT) at the Advanced Photon Source was supported by the United States Department of Energy , Basic Energy Sciences, Office of Science, under contract W-31-109-Eng-38 . Publisher Copyright: {\textcopyright} 2019",
year = "2019",
month = mar,
day = "19",
doi = "10.1016/j.immuni.2019.02.008",
language = "English",
volume = "50",
pages = "677--691.e13",
journal = "Immunity",
issn = "1074-7613",
number = "3",
}