Longitudinal Analysis Reveals Early Development of Three MPER-Directed Neutralizing Antibody Lineages from an HIV-1-Infected Individual

Shelly J. Krebs; Young D. Kwon; Chaim A. Schramm; William H. Law; Gina Donofrio; Kenneth H. Zhou; Syna Gift; Vincent Dussupt; Ivelin S. Georgiev; Sebastian Schätzle; Jonathan R. McDaniel; Yen Ting Lai; Mallika Sastry; Baoshan Zhang; Marissa C. Jarosinski; Amy Ransier; Agnes L. Chenine; Mangaiarkarasi Asokan; Robert T. Bailer; Meera Bose; Alberto Cagigi; Evan M. Cale; Gwo Yu Chuang; Samuel Darko; Jefferson I. Driscoll; Aliaksandr Druz; Jason Gorman; Farida Laboune; Mark K. Louder; Krisha McKee; Letzibeth Mendez; M. Anthony Moody; Anne Marie O'Sullivan; Christopher Owen; Dongjun Peng; Reda Rawi; Eric Sanders-Buell; Chen Hsiang Shen; Andrea R. Shiakolas; Tyler Stephens; Yaroslav Tsybovsky; Courtney Tucker; Raffaello Verardi; Keyun Wang; Jing Zhou; Tongqing Zhou; George Georgiou; S. Munir Alam; Barton F. Haynes; Morgane Rolland; Gary R. Matyas; Victoria R. Polonis; Adrian B. McDermott; Daniel C. Douek; Lawrence Shapiro; Sodsai Tovanabutra; Nelson L. Michael; John R. Mascola; Merlin L. Robb; Peter D. Kwong; Nicole A. Doria-Rose

doi:10.1016/j.immuni.2019.02.008

Longitudinal Analysis Reveals Early Development of Three MPER-Directed Neutralizing Antibody Lineages from an HIV-1-Infected Individual

Shelly J. Krebs, Young D. Kwon, Chaim A. Schramm, William H. Law, Gina Donofrio, Kenneth H. Zhou, Syna Gift, Vincent Dussupt, Ivelin S. Georgiev, Sebastian Schätzle, Jonathan R. McDaniel, Yen Ting Lai, Mallika Sastry, Baoshan Zhang, Marissa C. Jarosinski, Amy Ransier, Agnes L. Chenine, Mangaiarkarasi Asokan, Robert T. Bailer, Meera BoseAlberto Cagigi, Evan M. Cale, Gwo Yu Chuang, Samuel Darko, Jefferson I. Driscoll, Aliaksandr Druz, Jason Gorman, Farida Laboune, Mark K. Louder, Krisha McKee, Letzibeth Mendez, M. Anthony Moody, Anne Marie O'Sullivan, Christopher Owen, Dongjun Peng, Reda Rawi, Eric Sanders-Buell, Chen Hsiang Shen, Andrea R. Shiakolas, Tyler Stephens, Yaroslav Tsybovsky, Courtney Tucker, Raffaello Verardi, Keyun Wang, Jing Zhou, Tongqing Zhou, George Georgiou, S. Munir Alam, Barton F. Haynes, Morgane Rolland, Gary R. Matyas, Victoria R. Polonis, Adrian B. McDermott, Daniel C. Douek, Lawrence Shapiro, Sodsai Tovanabutra, Nelson L. Michael, John R. Mascola, Merlin L. Robb, Peter D. Kwong^*, Nicole A. Doria-Rose

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

64 Scopus citations

Abstract

Despite extensive structural work, little is known about how MPER-specific HIV antibodies develop. Krebs et al. describe the initiation and early development of three MPER-directed HIV broadly neutralizing antibody lineages from a single donor of the RV217 cohort. One of the antibody lineages appears particularly promising for vaccine design, as it achieved high neutralizing breadth with low mutation from germline.

Original language	English
Pages (from-to)	677-691.e13
Journal	Immunity
Volume	50
Issue number	3
DOIs	https://doi.org/10.1016/j.immuni.2019.02.008
State	Published - 19 Mar 2019
Externally published	Yes

Keywords

HIV envelope
neutralizing antibody
next-generation sequencing

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10.1016/j.immuni.2019.02.008

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Krebs, S. J., Kwon, Y. D., Schramm, C. A., Law, W. H., Donofrio, G., Zhou, K. H., Gift, S., Dussupt, V., Georgiev, I. S., Schätzle, S., McDaniel, J. R., Lai, Y. T., Sastry, M., Zhang, B., Jarosinski, M. C., Ransier, A., Chenine, A. L., Asokan, M., Bailer, R. T., ... Doria-Rose, N. A. (2019). Longitudinal Analysis Reveals Early Development of Three MPER-Directed Neutralizing Antibody Lineages from an HIV-1-Infected Individual. Immunity, 50(3), 677-691.e13. https://doi.org/10.1016/j.immuni.2019.02.008

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title = "Longitudinal Analysis Reveals Early Development of Three MPER-Directed Neutralizing Antibody Lineages from an HIV-1-Infected Individual",

abstract = "Despite extensive structural work, little is known about how MPER-specific HIV antibodies develop. Krebs et al. describe the initiation and early development of three MPER-directed HIV broadly neutralizing antibody lineages from a single donor of the RV217 cohort. One of the antibody lineages appears particularly promising for vaccine design, as it achieved high neutralizing breadth with low mutation from germline.",

keywords = "HIV envelope, neutralizing antibody, next-generation sequencing",

author = "Krebs, {Shelly J.} and Kwon, {Young D.} and Schramm, {Chaim A.} and Law, {William H.} and Gina Donofrio and Zhou, {Kenneth H.} and Syna Gift and Vincent Dussupt and Georgiev, {Ivelin S.} and Sebastian Sch{\"a}tzle and McDaniel, {Jonathan R.} and Lai, {Yen Ting} and Mallika Sastry and Baoshan Zhang and Jarosinski, {Marissa C.} and Amy Ransier and Chenine, {Agnes L.} and Mangaiarkarasi Asokan and Bailer, {Robert T.} and Meera Bose and Alberto Cagigi and Cale, {Evan M.} and Chuang, {Gwo Yu} and Samuel Darko and Driscoll, {Jefferson I.} and Aliaksandr Druz and Jason Gorman and Farida Laboune and Louder, {Mark K.} and Krisha McKee and Letzibeth Mendez and Moody, {M. Anthony} and O'Sullivan, {Anne Marie} and Christopher Owen and Dongjun Peng and Reda Rawi and Eric Sanders-Buell and Shen, {Chen Hsiang} and Shiakolas, {Andrea R.} and Tyler Stephens and Yaroslav Tsybovsky and Courtney Tucker and Raffaello Verardi and Keyun Wang and Jing Zhou and Tongqing Zhou and George Georgiou and Alam, {S. Munir} and Haynes, {Barton F.} and Morgane Rolland and Matyas, {Gary R.} and Polonis, {Victoria R.} and McDermott, {Adrian B.} and Douek, {Daniel C.} and Lawrence Shapiro and Sodsai Tovanabutra and Michael, {Nelson L.} and Mascola, {John R.} and Robb, {Merlin L.} and Kwong, {Peter D.} and Doria-Rose, {Nicole A.}",

note = "Publisher Copyright: {\textcopyright} 2019",

year = "2019",

month = mar,

day = "19",

doi = "10.1016/j.immuni.2019.02.008",

language = "English",

volume = "50",

pages = "677--691.e13",

journal = "Immunity",

issn = "1074-7613",

number = "3",

}

Krebs, SJ, Kwon, YD, Schramm, CA, Law, WH, Donofrio, G, Zhou, KH, Gift, S, Dussupt, V, Georgiev, IS, Schätzle, S, McDaniel, JR, Lai, YT, Sastry, M, Zhang, B, Jarosinski, MC, Ransier, A, Chenine, AL, Asokan, M, Bailer, RT, Bose, M, Cagigi, A, Cale, EM, Chuang, GY, Darko, S, Driscoll, JI, Druz, A, Gorman, J, Laboune, F, Louder, MK, McKee, K, Mendez, L, Moody, MA, O'Sullivan, AM, Owen, C, Peng, D, Rawi, R, Sanders-Buell, E, Shen, CH, Shiakolas, AR, Stephens, T, Tsybovsky, Y, Tucker, C, Verardi, R, Wang, K, Zhou, J, Zhou, T, Georgiou, G, Alam, SM, Haynes, BF, Rolland, M, Matyas, GR, Polonis, VR, McDermott, AB, Douek, DC, Shapiro, L, Tovanabutra, S, Michael, NL, Mascola, JR, Robb, ML, Kwong, PD & Doria-Rose, NA 2019, 'Longitudinal Analysis Reveals Early Development of Three MPER-Directed Neutralizing Antibody Lineages from an HIV-1-Infected Individual', Immunity, vol. 50, no. 3, pp. 677-691.e13. https://doi.org/10.1016/j.immuni.2019.02.008

TY - JOUR

T1 - Longitudinal Analysis Reveals Early Development of Three MPER-Directed Neutralizing Antibody Lineages from an HIV-1-Infected Individual

AU - Krebs, Shelly J.

AU - Kwon, Young D.

AU - Schramm, Chaim A.

AU - Law, William H.

AU - Donofrio, Gina

AU - Zhou, Kenneth H.

AU - Gift, Syna

AU - Dussupt, Vincent

AU - Georgiev, Ivelin S.

AU - Schätzle, Sebastian

AU - McDaniel, Jonathan R.

AU - Lai, Yen Ting

AU - Sastry, Mallika

AU - Zhang, Baoshan

AU - Jarosinski, Marissa C.

AU - Ransier, Amy

AU - Chenine, Agnes L.

AU - Asokan, Mangaiarkarasi

AU - Bailer, Robert T.

AU - Bose, Meera

AU - Cagigi, Alberto

AU - Cale, Evan M.

AU - Chuang, Gwo Yu

AU - Darko, Samuel

AU - Driscoll, Jefferson I.

AU - Druz, Aliaksandr

AU - Gorman, Jason

AU - Laboune, Farida

AU - Louder, Mark K.

AU - McKee, Krisha

AU - Mendez, Letzibeth

AU - Moody, M. Anthony

AU - O'Sullivan, Anne Marie

AU - Owen, Christopher

AU - Peng, Dongjun

AU - Rawi, Reda

AU - Sanders-Buell, Eric

AU - Shen, Chen Hsiang

AU - Shiakolas, Andrea R.

AU - Stephens, Tyler

AU - Tsybovsky, Yaroslav

AU - Tucker, Courtney

AU - Verardi, Raffaello

AU - Wang, Keyun

AU - Zhou, Jing

AU - Zhou, Tongqing

AU - Georgiou, George

AU - Alam, S. Munir

AU - Haynes, Barton F.

AU - Rolland, Morgane

AU - Matyas, Gary R.

AU - Polonis, Victoria R.

AU - McDermott, Adrian B.

AU - Douek, Daniel C.

AU - Shapiro, Lawrence

AU - Tovanabutra, Sodsai

AU - Michael, Nelson L.

AU - Mascola, John R.

AU - Robb, Merlin L.

AU - Kwong, Peter D.

AU - Doria-Rose, Nicole A.

PY - 2019/3/19

Y1 - 2019/3/19

N2 - Despite extensive structural work, little is known about how MPER-specific HIV antibodies develop. Krebs et al. describe the initiation and early development of three MPER-directed HIV broadly neutralizing antibody lineages from a single donor of the RV217 cohort. One of the antibody lineages appears particularly promising for vaccine design, as it achieved high neutralizing breadth with low mutation from germline.

AB - Despite extensive structural work, little is known about how MPER-specific HIV antibodies develop. Krebs et al. describe the initiation and early development of three MPER-directed HIV broadly neutralizing antibody lineages from a single donor of the RV217 cohort. One of the antibody lineages appears particularly promising for vaccine design, as it achieved high neutralizing breadth with low mutation from germline.

KW - HIV envelope

KW - neutralizing antibody

KW - next-generation sequencing

UR - http://www.scopus.com/inward/record.url?scp=85062872277&partnerID=8YFLogxK

U2 - 10.1016/j.immuni.2019.02.008

DO - 10.1016/j.immuni.2019.02.008

M3 - Article

C2 - 30876875

AN - SCOPUS:85062872277

SN - 1074-7613

VL - 50

SP - 677-691.e13

JO - Immunity

JF - Immunity

IS - 3

ER -

Longitudinal Analysis Reveals Early Development of Three MPER-Directed Neutralizing Antibody Lineages from an HIV-1-Infected Individual

Abstract

Keywords

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