Lymphoid interstitial pneumonia: Clinicopathological and immunopathological findings in 18 cases

Michael N. Koss, Liselotte Hochholzer*, John M. Langloss, William D. Wehunt, Angeline A. Lazarus

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

151 Scopus citations


Eighteen patients with lymphoid interstitial pneumonia (LIP) were studied. The diagnosis was established by the microscopic finding of interstitial infiltrates of lymphocytes and plasma cells. Forty-seven% of patients also had germinal centres, while 72% showed interstitial giant cells. Cases studied by the immunoperoxidase technique showed the interstitial plasma cells to be polytypic. The median age of patients was 56 years; most had cough, dyspnea, or chest pain. Chest X-rays showed either patchy interstitial infiltrates (usually bilateral) or poorly defined nodules. Ten patients had hypergammaglobulinemia; one had hypo-gammaglobulinemia. Two patients had Sjogren‘s syndrome, two had biopsy-proven chronic active hepatitis, and two had a clinical diagnosis of primary biliary cirrhosis. Follow-up examination of 14 patients showed clearing of symptoms, X-ray infiltrates or stable infiltrates in 4 cases each. Five patients died (mean survival, 41 months), one of whom succumbed to disseminated lymphoma and a second to respiratory failure. Our results support the hypothesis that LIP is a non-neoplastic cellular proliferation in which lymphoma may supervene. The high incidence (22%) of chronic liver disease has not previously been noted.

Original languageEnglish
Pages (from-to)178-185
Number of pages8
Issue number2
StatePublished - Apr 1987
Externally publishedYes


  • Interstitial pneumonitis
  • Lymphoma
  • Pneumonia
  • Pseudolymphoma of lung


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