Major histocompatibility complex genotype is associated with disease progression and virus load levels in a cohort of human immunodeficiency virus type 1-infected caucasians and African Americans

Dean L. Mann*, Robin P. Garner, Deborah E. Dayhoff, Kai Cao, Marcelo A. Fernández-Viña, Charles Davis, Naomi Aronson, Nancy Ruiz, Deborah L. Birx, Nelson L. Michael

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

To assess the influence of HLA on AIDS-free survival, human immunodeficiency virus load, and CD4 cell counts, 91 Caucasian and 48 African-American seroprevalent men were typed for HLA classes I and II and TAP alleles. HLA associations with these markers were assessed by assigning sum integer scores based on 7 class I allele-TAP variants (+1) and 13 class I-class II-TAP combinations (-1) with different AIDS-free survival times found in a prior study. Subjects in both racial groups and combined with positive sum scores were less likely to have CD4 cell decline (P = .0004), to have increased virus burden (P = .014), and to develop AIDS (P = .034) in the follow-up period than we Caucasians and African Americans with scores of 0 or -1. These results confirm the reported associations of specific major histocompatibility complex genes with AIDS-free survival time in Caucasians and specifically extend them to African Americans and to two established markers of disease progression.

Original languageEnglish
Pages (from-to)1799-1802
Number of pages4
JournalJournal of Infectious Diseases
Volume178
Issue number6
DOIs
StatePublished - 1998

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