Abstract
To assess the influence of HLA on AIDS-free survival, human immunodeficiency virus load, and CD4 cell counts, 91 Caucasian and 48 African-American seroprevalent men were typed for HLA classes I and II and TAP alleles. HLA associations with these markers were assessed by assigning sum integer scores based on 7 class I allele-TAP variants (+1) and 13 class I-class II-TAP combinations (-1) with different AIDS-free survival times found in a prior study. Subjects in both racial groups and combined with positive sum scores were less likely to have CD4 cell decline (P = .0004), to have increased virus burden (P = .014), and to develop AIDS (P = .034) in the follow-up period than we Caucasians and African Americans with scores of 0 or -1. These results confirm the reported associations of specific major histocompatibility complex genes with AIDS-free survival time in Caucasians and specifically extend them to African Americans and to two established markers of disease progression.
Original language | English |
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Pages (from-to) | 1799-1802 |
Number of pages | 4 |
Journal | Journal of Infectious Diseases |
Volume | 178 |
Issue number | 6 |
DOIs | |
State | Published - 1998 |