Management of patients with pancreatic cysts

Thomas Kowalski*, Ali Siddiqui, David Loren, Howard R. Mertz, Damien Mallat, Nadim Haddad, Nidhi Malhotra, Brett Sadowski, Mark J. Lybik, Sandeep N. Patel, Emuejevoke Okoh, Laura Rosenkranz, Michael Karasik, Michael Golioto, Jeffrey Linder, Marc F. Catalano, Mohammad A. Al-Haddad

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Goals: To examine the utility of integrated molecular pathology (IMP) in managing surveillance of pancreatic cysts based on outcomes and analysis of false negatives (FNs) from a previously published cohort (n=492). Background: In endoscopic ultrasound with fine-needle aspiration (EUS-FNA) of cyst fluid lacking malignant cytology, IMP demonstrated better risk stratification for malignancy at approximately 3 years' follow-up than International Consensus Guideline (Fukuoka) 2012 management recommendations in such cases. Study: Patient outcomes and clinical features of Fukuoka and IMP FN cases were reviewed. Practical guidance for appropriate surveillance intervals and surgery decisions using IMP were derived from follow-up data, considering EUS-FNA sampling limitations and high-risk clinical circumstances observed. Surveillance intervals for patients based on IMP predictive value were compared with those of Fukuoka. Results: Outcomes at follow-up for IMP low-risk diagnoses supported surveillance every 2 to 3 years, independent of cyst size, when EUS-FNA sampling limitations or high-risk clinical circumstances were absent. In 10 of 11 patients with FN IMP diagnoses (2% of cohort), EUS-FNA sampling limitations existed; Fukuoka identified high risk in 9 of 11 cases. In 4 of 6 FN cases by Fukuoka (1% of cohort), IMP identified high risk. Overall, 55% of cases had possible sampling limitations and 37% had high-risk clinical circumstances. Outcomes support more cautious management in such cases when using IMP. Conclusions: Adjunct use of IMP can provide evidence for relaxed surveillance of patients with benign cysts that meet Fukuoka criteria for closer observation or surgery. Although infrequent, FN results with IMP can be associated with EUS-FNA sampling limitations or high-risk clinical circumstances.

Original languageEnglish
Pages (from-to)649-657
Number of pages9
JournalJournal of Clinical Gastroenterology
Issue number8
StatePublished - 2016
Externally publishedYes


  • disease management
  • endoscopic ultrasound-guided fine-needle aspiration
  • pancreatic cyst
  • risk


Dive into the research topics of 'Management of patients with pancreatic cysts'. Together they form a unique fingerprint.

Cite this