Management of Postmenopausal Osteoporosis: ACOG Clinical Practice Guideline No. 2

Jo Ann V. Pinkerton, David Chelmow, Catherine T. Witkop

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

PURPOSE:To provide updated evidence-based recommendations for the treatment of postmenopausal osteoporosis.TARGET POPULATION:Postmenopausal patients with primary osteoporosis.METHODS:This guideline was developed using an a priori protocol in conjunction with a writing team consisting of two specialists in obstetrics and gynecology appointed by the ACOG Committee on Clinical Practice Guidelines-Gynecology and one external subject matter expert. ACOG medical librarians completed a comprehensive literature search for primary literature within Cochrane Library, Cochrane Collaboration Registry of Controlled Trials, EMBASE, PubMed, and MEDLINE. Studies that moved forward to the full-text screening stage were assessed by two authors from the writing team based on standardized inclusion and exclusion criteria. Included studies underwent quality assessment, and a modified GRADE (Grading of Recommendations Assessment, Development, and Evaluation) evidence-to-decision framework was applied to interpret and translate the evidence into recommendation statements.RECOMMENDATIONS:This Clinical Practice Guideline includes updated recommendations on who should receive osteoporosis pharmacotherapy, the benefits and risks of available pharmacotherapy options, treatment monitoring and follow-up, and the role of calcium and vitamin D in the management of postmenopausal osteoporosis. Recommendations are classified by strength and evidence quality. Ungraded Good Practice Points are included to provide guidance when a formal recommendation could not be made because of inadequate or nonexistent evidence.

Original languageEnglish
Pages (from-to)698-717
Number of pages20
JournalObstetrics and gynecology
Volume139
Issue number4
DOIs
StatePublished - 1 Apr 2022

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