Marked hypofibrinogenemia and gastrointestinal bleeding after copperhead (Agkistrodon contortrix) envenomation

Kathryn T. Kopec*, May Yen, Matthew Bitner, C. Scott Evans, Charles J. Gerardo

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Compared with other crotaline envenomations, copperhead envenomations have historically been reported as having less severe hematologic venom effects and rarely hemorrhage. We report a case of clinically significant gastrointestinal bleeding after a copperhead (Agkistrodon contortrix) envenomation. A 52-year-old woman with a history of systemic lupus erythematosus was bitten on her right medial ankle after which hypofibrinogenemia and hematochezia developed. The symptoms resolved after repeated administration of Crotalidae polyvalent immune Fab (ovine) antivenom. She was discharged without further complications 2 days later. Although copperhead envenomations are classically considered less severe than other crotaline envenomations, this case demonstrates the potential of the venom to produce clinically significant hematologic effects.

Original languageEnglish
Pages (from-to)488-490
Number of pages3
JournalWilderness and Environmental Medicine
Issue number4
StatePublished - 1 Dec 2015
Externally publishedYes


  • Agkistrodon contortrix
  • copperhead
  • envenomation
  • gastrointestinal bleeding
  • hypofibrinogenemia


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