Mass Spectrometry-Based Proteomic Approaches for Disease Diagnosis and Biomarker Discovery

Thomas P. Conrads*, Haleem J. Issaq, Josip S. Blonder, Timothy D. Veenstra

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


The ability of proteomic technologies to interrogate thousands of proteins found in complex biological samples has brought with it the hope of discovering novel disease-specific biomarkers. While most of the proteomic technologies used to discover diagnostic biomarkers are quite sophisticated, "proteomic pattern analysis" has emerged as a simple, yet potentially revolutionary, method for the early diagnosis of diseases such as ovarian cancer. Utilizing this technology, hundreds of clinical samples per day can be analyzed and several preliminary studies suggest proteomic pattern analysis has the potential to be a novel, highly sensitive diagnostic tool for the early detection of cancer.

Original languageEnglish
Title of host publicationIntegrated Strategies for Drug Discovery Using Mass Spectrometry
PublisherJohn Wiley & Sons, Inc.
Number of pages26
ISBN (Print)047146127X, 9780471461272
StatePublished - 27 Jan 2005
Externally publishedYes


  • Bioinformatics
  • Biomarkers
  • Cancer
  • Diagnostic medicine
  • Mass spectrometry
  • Proteomic pattern analysis


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