Mass Spectrometry-Based Proteomic Approaches for Disease Diagnosis and Biomarker Discovery

Thomas P. Conrads; Haleem J. Issaq; Josip S. Blonder; Timothy D. Veenstra

doi:10.1002/0471721034.ch4

Mass Spectrometry-Based Proteomic Approaches for Disease Diagnosis and Biomarker Discovery

Thomas P. Conrads^*, Haleem J. Issaq, Josip S. Blonder, Timothy D. Veenstra

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

The ability of proteomic technologies to interrogate thousands of proteins found in complex biological samples has brought with it the hope of discovering novel disease-specific biomarkers. While most of the proteomic technologies used to discover diagnostic biomarkers are quite sophisticated, "proteomic pattern analysis" has emerged as a simple, yet potentially revolutionary, method for the early diagnosis of diseases such as ovarian cancer. Utilizing this technology, hundreds of clinical samples per day can be analyzed and several preliminary studies suggest proteomic pattern analysis has the potential to be a novel, highly sensitive diagnostic tool for the early detection of cancer.

Original language	English
Title of host publication	Integrated Strategies for Drug Discovery Using Mass Spectrometry
Publisher	John Wiley & Sons, Inc.
Pages	95-120
Number of pages	26
ISBN (Print)	047146127X, 9780471461272
DOIs	https://doi.org/10.1002/0471721034.ch4
State	Published - 27 Jan 2005
Externally published	Yes

Keywords

Bioinformatics
Biomarkers
Cancer
Diagnostic medicine
Mass spectrometry
Proteomic pattern analysis

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10.1002/0471721034.ch4

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title = "Mass Spectrometry-Based Proteomic Approaches for Disease Diagnosis and Biomarker Discovery",

abstract = "The ability of proteomic technologies to interrogate thousands of proteins found in complex biological samples has brought with it the hope of discovering novel disease-specific biomarkers. While most of the proteomic technologies used to discover diagnostic biomarkers are quite sophisticated, {"}proteomic pattern analysis{"} has emerged as a simple, yet potentially revolutionary, method for the early diagnosis of diseases such as ovarian cancer. Utilizing this technology, hundreds of clinical samples per day can be analyzed and several preliminary studies suggest proteomic pattern analysis has the potential to be a novel, highly sensitive diagnostic tool for the early detection of cancer.",

keywords = "Bioinformatics, Biomarkers, Cancer, Diagnostic medicine, Mass spectrometry, Proteomic pattern analysis",

author = "Conrads, {Thomas P.} and Issaq, {Haleem J.} and Blonder, {Josip S.} and Veenstra, {Timothy D.}",

year = "2005",

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doi = "10.1002/0471721034.ch4",

language = "English",

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AU - Conrads, Thomas P.

AU - Issaq, Haleem J.

AU - Blonder, Josip S.

AU - Veenstra, Timothy D.

PY - 2005/1/27

Y1 - 2005/1/27

N2 - The ability of proteomic technologies to interrogate thousands of proteins found in complex biological samples has brought with it the hope of discovering novel disease-specific biomarkers. While most of the proteomic technologies used to discover diagnostic biomarkers are quite sophisticated, "proteomic pattern analysis" has emerged as a simple, yet potentially revolutionary, method for the early diagnosis of diseases such as ovarian cancer. Utilizing this technology, hundreds of clinical samples per day can be analyzed and several preliminary studies suggest proteomic pattern analysis has the potential to be a novel, highly sensitive diagnostic tool for the early detection of cancer.

AB - The ability of proteomic technologies to interrogate thousands of proteins found in complex biological samples has brought with it the hope of discovering novel disease-specific biomarkers. While most of the proteomic technologies used to discover diagnostic biomarkers are quite sophisticated, "proteomic pattern analysis" has emerged as a simple, yet potentially revolutionary, method for the early diagnosis of diseases such as ovarian cancer. Utilizing this technology, hundreds of clinical samples per day can be analyzed and several preliminary studies suggest proteomic pattern analysis has the potential to be a novel, highly sensitive diagnostic tool for the early detection of cancer.

KW - Bioinformatics

KW - Biomarkers

KW - Cancer

KW - Diagnostic medicine

KW - Mass spectrometry

KW - Proteomic pattern analysis

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DO - 10.1002/0471721034.ch4

M3 - Chapter

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SN - 9780471461272

SP - 95

EP - 120

BT - Integrated Strategies for Drug Discovery Using Mass Spectrometry

PB - John Wiley & Sons, Inc.

ER -

Mass Spectrometry-Based Proteomic Approaches for Disease Diagnosis and Biomarker Discovery

Abstract

Keywords

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