Massive Transfusion in Pediatric Patients

Lucas P. Neff*, Michael Aaron Beckwith, Robert T. Russell, Jeremy W. Cannon, Philip C. Spinella

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations


Massive transfusion in pediatric patients is infrequent but associated with much higher mortality than in adults. Blood transfusion and hematology has conceptualized ideas such as blood failure and the interplay of the blood-endothelium interface to understand coagulopathy in the context of hemorrhagic shock. Researchers are still searching for an appropriate definition of what constitutes a pediatric massive transfusion. There is no universally accepted protocol for massive transfusion and how to address the many complications that can arise. Pharmacologic adjuncts to resuscitation may prove beneficial in reducing coagulopathy during pediatric massive transfusion, but high-quality evidence has not yet emerged.

Original languageEnglish
Pages (from-to)35-49
Number of pages15
JournalClinics in Laboratory Medicine
Issue number1
StatePublished - Mar 2021
Externally publishedYes


  • Blood failure
  • Endotheliopathy
  • Hemorrhage
  • Pediatric massive transfusion
  • Whole blood


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