Matrix Bound Nanovesicles Have Tissue-Specific Characteristics That Suggest a Regulatory Role

Neill J. Turner, Lina M. Quijano, George S. Hussey, Peng Jiang, Stephen F. Badylak*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Recent studies have identified an extracellular vesicle population that is tightly anchored within the extracellular matrix (ECM) of tissues and organs until released by matrix turnover events. Evidence suggests that these matrix-bound nanovesicles (MBVs) are a ubiquitous component of the ECM, raising questions regarding their tissue-specific identity and their biologic function(s). The primary objective of this study was to examine MBVs isolated from six different tissues and compare their physical and compositional characteristics to determine the common and differentially expressed features. Accordingly, the results of this characterization show that while MBVs are a ubiquitous component of the ECM, they contain a protein and microRNA cargo that is tissue specific. The results furthermore suggest that MBVs have an important role in regulating tissue homeostasis.

Original languageEnglish
Pages (from-to)879-892
Number of pages14
JournalTissue Engineering - Part A.
Volume28
Issue number21-22
DOIs
StatePublished - Nov 2022
Externally publishedYes

Keywords

  • extracellular matrix
  • extracellular vesicles
  • matrix-bound nanovesicles
  • microvesicles

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