Measurement of Acetylcholine Receptor Function in Microcircuit-Coupled Myoblasts

Judy N. Quong; Thomas L. Fare; Howard J. Bryant; David A. Stenger

doi:10.1109/10.245629

Measurement of Acetylcholine Receptor Function in Microcircuit-Coupled Myoblasts

Judy N. Quong, Thomas L. Fare, Howard J. Bryant, David A. Stenger

Anatomy, Physiology, and Genetics

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

An electrophysiological measurement principle for long-term, noninvasive monitoring of the nicotinic acetylcholine receptor (nAChR) function is described. The measurement is based on the ability to record agonist-induced depolarizations of clonal myoblasts that have formed high impedance seals with extracellular microcircuit electrodes. The technique appears promising for several types of assays and environmental monitoring applications.

Original language	English
Pages (from-to)	1122-1126
Number of pages	5
Journal	IEEE Transactions on Biomedical Engineering
Volume	40
Issue number	11
DOIs	https://doi.org/10.1109/10.245629
State	Published - Nov 1993

Access to Document

10.1109/10.245629

Cite this

@article{27c82fb7c7c24c52a82fb873e26b838b,

title = "Measurement of Acetylcholine Receptor Function in Microcircuit-Coupled Myoblasts",

abstract = "An electrophysiological measurement principle for long-term, noninvasive monitoring of the nicotinic acetylcholine receptor (nAChR) function is described. The measurement is based on the ability to record agonist-induced depolarizations of clonal myoblasts that have formed high impedance seals with extracellular microcircuit electrodes. The technique appears promising for several types of assays and environmental monitoring applications.",

author = "Quong, \{Judy N.\} and Fare, \{Thomas L.\} and Bryant, \{Howard J.\} and Stenger, \{David A.\}",

year = "1993",

month = nov,

doi = "10.1109/10.245629",

language = "English",

volume = "40",

pages = "1122--1126",

journal = "IEEE Transactions on Biomedical Engineering",

issn = "0018-9294",

publisher = "IEEE Computer Society",

number = "11",

}

TY - JOUR

T1 - Measurement of Acetylcholine Receptor Function in Microcircuit-Coupled Myoblasts

AU - Quong, Judy N.

AU - Fare, Thomas L.

AU - Bryant, Howard J.

AU - Stenger, David A.

PY - 1993/11

Y1 - 1993/11

N2 - An electrophysiological measurement principle for long-term, noninvasive monitoring of the nicotinic acetylcholine receptor (nAChR) function is described. The measurement is based on the ability to record agonist-induced depolarizations of clonal myoblasts that have formed high impedance seals with extracellular microcircuit electrodes. The technique appears promising for several types of assays and environmental monitoring applications.

AB - An electrophysiological measurement principle for long-term, noninvasive monitoring of the nicotinic acetylcholine receptor (nAChR) function is described. The measurement is based on the ability to record agonist-induced depolarizations of clonal myoblasts that have formed high impedance seals with extracellular microcircuit electrodes. The technique appears promising for several types of assays and environmental monitoring applications.

UR - http://www.scopus.com/inward/record.url?scp=0027691250&partnerID=8YFLogxK

U2 - 10.1109/10.245629

DO - 10.1109/10.245629

M3 - Article

C2 - 8307595

AN - SCOPUS:0027691250

SN - 0018-9294

VL - 40

SP - 1122

EP - 1126

JO - IEEE Transactions on Biomedical Engineering

JF - IEEE Transactions on Biomedical Engineering

IS - 11

ER -

Measurement of Acetylcholine Receptor Function in Microcircuit-Coupled Myoblasts

Abstract

Access to Document

Fingerprint

Cite this