Mechanisms by which acellular biologic scaffolds promote functional skeletal muscle restoration

Stephen F. Badylak; Jenna L. Dziki; Brian M. Sicari; Fabrisia Ambrosio; Michael L. Boninger

doi:10.1016/j.biomaterials.2016.06.047

Mechanisms by which acellular biologic scaffolds promote functional skeletal muscle restoration

Stephen F. Badylak^*, Jenna L. Dziki, Brian M. Sicari, Fabrisia Ambrosio, Michael L. Boninger

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

58 Scopus citations

Abstract

Acellular biologic scaffolds derived from extracellular matrix have been investigated in preclinical and clinical studies as a regenerative medicine approach for volumetric muscle loss treatment. The present manuscript provides a review of previous studies supporting the use of extracellular matrix derived biologic scaffolds for the promotion of functional skeletal muscle tissue formation that is contractile and innervated.

Original language	English
Pages (from-to)	128-136
Number of pages	9
Journal	Biomaterials
Volume	103
DOIs	https://doi.org/10.1016/j.biomaterials.2016.06.047
State	Published - 1 Oct 2016
Externally published	Yes

Keywords

Biologic scaffold
Extracellular matrix
Volumetric muscle loss

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10.1016/j.biomaterials.2016.06.047

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title = "Mechanisms by which acellular biologic scaffolds promote functional skeletal muscle restoration",

abstract = "Acellular biologic scaffolds derived from extracellular matrix have been investigated in preclinical and clinical studies as a regenerative medicine approach for volumetric muscle loss treatment. The present manuscript provides a review of previous studies supporting the use of extracellular matrix derived biologic scaffolds for the promotion of functional skeletal muscle tissue formation that is contractile and innervated.",

keywords = "Biologic scaffold, Extracellular matrix, Volumetric muscle loss",

author = "Badylak, {Stephen F.} and Dziki, {Jenna L.} and Sicari, {Brian M.} and Fabrisia Ambrosio and Boninger, {Michael L.}",

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AU - Badylak, Stephen F.

AU - Dziki, Jenna L.

AU - Sicari, Brian M.

AU - Ambrosio, Fabrisia

AU - Boninger, Michael L.

PY - 2016/10/1

Y1 - 2016/10/1

N2 - Acellular biologic scaffolds derived from extracellular matrix have been investigated in preclinical and clinical studies as a regenerative medicine approach for volumetric muscle loss treatment. The present manuscript provides a review of previous studies supporting the use of extracellular matrix derived biologic scaffolds for the promotion of functional skeletal muscle tissue formation that is contractile and innervated.

AB - Acellular biologic scaffolds derived from extracellular matrix have been investigated in preclinical and clinical studies as a regenerative medicine approach for volumetric muscle loss treatment. The present manuscript provides a review of previous studies supporting the use of extracellular matrix derived biologic scaffolds for the promotion of functional skeletal muscle tissue formation that is contractile and innervated.

KW - Biologic scaffold

KW - Extracellular matrix

KW - Volumetric muscle loss

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DO - 10.1016/j.biomaterials.2016.06.047

M3 - Article

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VL - 103

SP - 128

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JO - Biomaterials

JF - Biomaterials

ER -

Mechanisms by which acellular biologic scaffolds promote functional skeletal muscle restoration

Abstract

Keywords

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