Mechanisms by which acellular biologic scaffolds promote functional skeletal muscle restoration

Stephen F. Badylak*, Jenna L. Dziki, Brian M. Sicari, Fabrisia Ambrosio, Michael L. Boninger

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

56 Scopus citations

Abstract

Acellular biologic scaffolds derived from extracellular matrix have been investigated in preclinical and clinical studies as a regenerative medicine approach for volumetric muscle loss treatment. The present manuscript provides a review of previous studies supporting the use of extracellular matrix derived biologic scaffolds for the promotion of functional skeletal muscle tissue formation that is contractile and innervated.

Original languageEnglish
Pages (from-to)128-136
Number of pages9
JournalBiomaterials
Volume103
DOIs
StatePublished - 1 Oct 2016
Externally publishedYes

Keywords

  • Biologic scaffold
  • Extracellular matrix
  • Volumetric muscle loss

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