Mechanisms in immune tolerance.

D. W. Scott*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations


Self:nonself-discrimination is critical for the function of the immune system and survival of vertebrate species. The failure to respond to one's own antigens has been called self-tolerance. The mechanisms whereby such tolerance may be induced are reviewed herein. Emphasis is placed on the role of self-recognition involving suppressor T-cell pathways as well as on studies involving putative clonal deletion mechanisms. The important parameters for the induction of tolerance and the roles played by surface isotypes in discriminating immunogenic vs. tolerogenic signals will be emphasized. The possible involvement of multiple pathways for self or experimental tolerance is emphasized with the ultimate goal being the modulation of aberrant immune responses.

Original languageEnglish
Pages (from-to)1-25
Number of pages25
JournalCritical reviews in immunology
Issue number1
StatePublished - 1984


Dive into the research topics of 'Mechanisms in immune tolerance.'. Together they form a unique fingerprint.

Cite this