TY - JOUR
T1 - Mechanisms of bone development and repair
AU - Salhotra, Ankit
AU - Shah, Harsh N.
AU - Levi, Benjamin
AU - Longaker, Michael T.
N1 - Publisher Copyright:
© 2020, Springer Nature Limited.
PY - 2020/11/1
Y1 - 2020/11/1
N2 - Bone development occurs through a series of synchronous events that result in the formation of the body scaffold. The repair potential of bone and its surrounding microenvironment — including inflammatory, endothelial and Schwann cells — persists throughout adulthood, enabling restoration of tissue to its homeostatic functional state. The isolation of a single skeletal stem cell population through cell surface markers and the development of single-cell technologies are enabling precise elucidation of cellular activity and fate during bone repair by providing key insights into the mechanisms that maintain and regenerate bone during homeostasis and repair. Increased understanding of bone development, as well as normal and aberrant bone repair, has important therapeutic implications for the treatment of bone disease and ageing-related degeneration.
AB - Bone development occurs through a series of synchronous events that result in the formation of the body scaffold. The repair potential of bone and its surrounding microenvironment — including inflammatory, endothelial and Schwann cells — persists throughout adulthood, enabling restoration of tissue to its homeostatic functional state. The isolation of a single skeletal stem cell population through cell surface markers and the development of single-cell technologies are enabling precise elucidation of cellular activity and fate during bone repair by providing key insights into the mechanisms that maintain and regenerate bone during homeostasis and repair. Increased understanding of bone development, as well as normal and aberrant bone repair, has important therapeutic implications for the treatment of bone disease and ageing-related degeneration.
UR - http://www.scopus.com/inward/record.url?scp=85090446290&partnerID=8YFLogxK
U2 - 10.1038/s41580-020-00279-w
DO - 10.1038/s41580-020-00279-w
M3 - Review article
C2 - 32901139
AN - SCOPUS:85090446290
SN - 1471-0072
VL - 21
SP - 696
EP - 711
JO - Nature Reviews Molecular Cell Biology
JF - Nature Reviews Molecular Cell Biology
IS - 11
ER -