Mechanisms of carbapenem resistance among a collection of Enterobacteriaceae clinical isolates in a Texas city

Jason W. Bennett; Katrin Mende; Monica L. Herrera; Xin Yu; James S. Lewis; Brian L. Wickes; James H. Jorgensen; Clinton K. Murray

doi:10.1016/j.diagmicrobio.2009.11.013

Mechanisms of carbapenem resistance among a collection of Enterobacteriaceae clinical isolates in a Texas city

Jason W. Bennett, Katrin Mende, Monica L. Herrera, Xin Yu, James S. Lewis, Brian L. Wickes, James H. Jorgensen, Clinton K. Murray^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Fourteen Enterobacteriaceae isolates with ertapenem MIC >2 mg/mL were analyzed to identify mechanisms of resistance. All isolates produced extended-spectrum β-lactamase or AmpC β-lactamase with variable, but decreased, expression of outer membrane proteins. One Enterobacter cloacae produced derepressed AmpC β-lactamase, 1 Escherichia coli expressed plasmid-mediated AmpC β-lactamase, and 1 E. cloacae produced a carbapenemase.

Original language	English
Pages (from-to)	445-448
Number of pages	4
Journal	Diagnostic Microbiology and Infectious Disease
Volume	66
Issue number	4
DOIs	https://doi.org/10.1016/j.diagmicrobio.2009.11.013
State	Published - Apr 2010

Keywords

AmpC beta-lactamase
Carbapenem
Enterobacteriaceae
Extended spectrum beta-lactamases
KPC-2
Porins
Texas city

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10.1016/j.diagmicrobio.2009.11.013

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title = "Mechanisms of carbapenem resistance among a collection of Enterobacteriaceae clinical isolates in a Texas city",

abstract = "Fourteen Enterobacteriaceae isolates with ertapenem MIC >2 mg/mL were analyzed to identify mechanisms of resistance. All isolates produced extended-spectrum β-lactamase or AmpC β-lactamase with variable, but decreased, expression of outer membrane proteins. One Enterobacter cloacae produced derepressed AmpC β-lactamase, 1 Escherichia coli expressed plasmid-mediated AmpC β-lactamase, and 1 E. cloacae produced a carbapenemase.",

keywords = "AmpC beta-lactamase, Carbapenem, Enterobacteriaceae, Extended spectrum beta-lactamases, KPC-2, Porins, Texas city",

author = "Bennett, {Jason W.} and Katrin Mende and Herrera, {Monica L.} and Xin Yu and Lewis, {James S.} and Wickes, {Brian L.} and Jorgensen, {James H.} and Murray, {Clinton K.}",

year = "2010",

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volume = "66",

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T1 - Mechanisms of carbapenem resistance among a collection of Enterobacteriaceae clinical isolates in a Texas city

AU - Bennett, Jason W.

AU - Mende, Katrin

AU - Herrera, Monica L.

AU - Yu, Xin

AU - Lewis, James S.

AU - Wickes, Brian L.

AU - Jorgensen, James H.

AU - Murray, Clinton K.

PY - 2010/4

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N2 - Fourteen Enterobacteriaceae isolates with ertapenem MIC >2 mg/mL were analyzed to identify mechanisms of resistance. All isolates produced extended-spectrum β-lactamase or AmpC β-lactamase with variable, but decreased, expression of outer membrane proteins. One Enterobacter cloacae produced derepressed AmpC β-lactamase, 1 Escherichia coli expressed plasmid-mediated AmpC β-lactamase, and 1 E. cloacae produced a carbapenemase.

AB - Fourteen Enterobacteriaceae isolates with ertapenem MIC >2 mg/mL were analyzed to identify mechanisms of resistance. All isolates produced extended-spectrum β-lactamase or AmpC β-lactamase with variable, but decreased, expression of outer membrane proteins. One Enterobacter cloacae produced derepressed AmpC β-lactamase, 1 Escherichia coli expressed plasmid-mediated AmpC β-lactamase, and 1 E. cloacae produced a carbapenemase.

KW - AmpC beta-lactamase

KW - Carbapenem

KW - Enterobacteriaceae

KW - Extended spectrum beta-lactamases

KW - KPC-2

KW - Porins

KW - Texas city

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AN - SCOPUS:77649334726

SN - 0732-8893

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JO - Diagnostic Microbiology and Infectious Disease

JF - Diagnostic Microbiology and Infectious Disease

IS - 4

ER -

Mechanisms of carbapenem resistance among a collection of Enterobacteriaceae clinical isolates in a Texas city

Abstract

Keywords

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