Mechanisms of hepatoprotection by nitric oxide

Yinna Wang, Yoram Vodovotz, Peter K.M. Kim, Ruben Zamora, Timothy R. Billiar*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

58 Scopus citations


Nitric oxide (NO) exerts numerous antiapoptotic effects on hepatocytes in settings of inflammation and tissue damage. These actions of NO are modulated by a variety of mechanisms under both physiologic and pathologic conditions. Nitric oxide inhibits cell death or apoptosis by modulation of heat shock proteins, S-nitrosylation of caspases at their catalytic site cysteine residue, triggering of the cGMP pathway, and prevention of mitochondrial dysfunction. Our preliminary studies also suggest that NO can modulate apoptosis-related genes in a manner consistent with an antiapoptotic effect. This review focuses on these molecular mechanisms of cytoprotection by NO.

Original languageEnglish
Pages (from-to)415-422
Number of pages8
JournalAnnals of the New York Academy of Sciences
StatePublished - 2002
Externally publishedYes


Dive into the research topics of 'Mechanisms of hepatoprotection by nitric oxide'. Together they form a unique fingerprint.

Cite this