Mechanisms of hepatoprotection by nitric oxide

Yinna Wang; Yoram Vodovotz; Peter K.M. Kim; Ruben Zamora; Timothy R. Billiar

doi:10.1111/j.1749-6632.2002.tb04085.x

Mechanisms of hepatoprotection by nitric oxide

Yinna Wang, Yoram Vodovotz, Peter K.M. Kim, Ruben Zamora, Timothy R. Billiar^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

60 Scopus citations

Abstract

Nitric oxide (NO) exerts numerous antiapoptotic effects on hepatocytes in settings of inflammation and tissue damage. These actions of NO are modulated by a variety of mechanisms under both physiologic and pathologic conditions. Nitric oxide inhibits cell death or apoptosis by modulation of heat shock proteins, S-nitrosylation of caspases at their catalytic site cysteine residue, triggering of the cGMP pathway, and prevention of mitochondrial dysfunction. Our preliminary studies also suggest that NO can modulate apoptosis-related genes in a manner consistent with an antiapoptotic effect. This review focuses on these molecular mechanisms of cytoprotection by NO.

Original language	English
Pages (from-to)	415-422
Number of pages	8
Journal	Annals of the New York Academy of Sciences
Volume	962
DOIs	https://doi.org/10.1111/j.1749-6632.2002.tb04085.x
State	Published - 2002
Externally published	Yes

Access to Document

10.1111/j.1749-6632.2002.tb04085.x

Cite this

@article{e1257b6b947d4ce1a33e2efa1fbc7bf2,

title = "Mechanisms of hepatoprotection by nitric oxide",

abstract = "Nitric oxide (NO) exerts numerous antiapoptotic effects on hepatocytes in settings of inflammation and tissue damage. These actions of NO are modulated by a variety of mechanisms under both physiologic and pathologic conditions. Nitric oxide inhibits cell death or apoptosis by modulation of heat shock proteins, S-nitrosylation of caspases at their catalytic site cysteine residue, triggering of the cGMP pathway, and prevention of mitochondrial dysfunction. Our preliminary studies also suggest that NO can modulate apoptosis-related genes in a manner consistent with an antiapoptotic effect. This review focuses on these molecular mechanisms of cytoprotection by NO.",

author = "Yinna Wang and Yoram Vodovotz and Kim, {Peter K.M.} and Ruben Zamora and Billiar, {Timothy R.}",

year = "2002",

doi = "10.1111/j.1749-6632.2002.tb04085.x",

language = "English",

volume = "962",

pages = "415--422",

journal = "Annals of the New York Academy of Sciences",

issn = "0077-8923",

publisher = "John Wiley and Sons Inc",

}

TY - JOUR

T1 - Mechanisms of hepatoprotection by nitric oxide

AU - Wang, Yinna

AU - Vodovotz, Yoram

AU - Kim, Peter K.M.

AU - Zamora, Ruben

AU - Billiar, Timothy R.

PY - 2002

Y1 - 2002

N2 - Nitric oxide (NO) exerts numerous antiapoptotic effects on hepatocytes in settings of inflammation and tissue damage. These actions of NO are modulated by a variety of mechanisms under both physiologic and pathologic conditions. Nitric oxide inhibits cell death or apoptosis by modulation of heat shock proteins, S-nitrosylation of caspases at their catalytic site cysteine residue, triggering of the cGMP pathway, and prevention of mitochondrial dysfunction. Our preliminary studies also suggest that NO can modulate apoptosis-related genes in a manner consistent with an antiapoptotic effect. This review focuses on these molecular mechanisms of cytoprotection by NO.

AB - Nitric oxide (NO) exerts numerous antiapoptotic effects on hepatocytes in settings of inflammation and tissue damage. These actions of NO are modulated by a variety of mechanisms under both physiologic and pathologic conditions. Nitric oxide inhibits cell death or apoptosis by modulation of heat shock proteins, S-nitrosylation of caspases at their catalytic site cysteine residue, triggering of the cGMP pathway, and prevention of mitochondrial dysfunction. Our preliminary studies also suggest that NO can modulate apoptosis-related genes in a manner consistent with an antiapoptotic effect. This review focuses on these molecular mechanisms of cytoprotection by NO.

UR - http://www.scopus.com/inward/record.url?scp=0036268905&partnerID=8YFLogxK

U2 - 10.1111/j.1749-6632.2002.tb04085.x

DO - 10.1111/j.1749-6632.2002.tb04085.x

M3 - Article

C2 - 12076992

AN - SCOPUS:0036268905

SN - 0077-8923

VL - 962

SP - 415

EP - 422

JO - Annals of the New York Academy of Sciences

JF - Annals of the New York Academy of Sciences

ER -

Mechanisms of hepatoprotection by nitric oxide

Abstract

Access to Document

Fingerprint

Cite this