TY - JOUR
T1 - Medical applications of microarray technologies
T2 - A regulatory science perspective
AU - Petricoin, Emanuel F.
AU - Hackett, Joseph L.
AU - Lesko, Lawrence J.
AU - Puri, Raj K.
AU - Gutman, Steven I.
AU - Chumakov, Konstantin
AU - Woodcock, Janet
AU - Feigal, David W.
AU - Zoon, Kathryn C.
AU - Sistare, Frank D.
PY - 2002/12
Y1 - 2002/12
N2 - The potential medical applications of microarrays have generated much excitement, and some skepticism, within the biomedical community. Some researchers have suggested that within the decade microarrays will be routinely used in the selection, assessment, and quality control of the best drugs for pharmaceutical development, as well as for disease diagnosis and for monitoring desired and adverse outcomes of therapeutic interventions. Realizing this potential will be a challenge for the whole scientific community, as breakthroughs that show great promise at the bench often fail to meet the requirements of clinicians and regulatory scientists. The development of a cooperative framework among regulators, product sponsors, and technology experts will be essential for realizing the revolutionary promise that microarrays hold for drug development, regulatory science, medical practice and public health.
AB - The potential medical applications of microarrays have generated much excitement, and some skepticism, within the biomedical community. Some researchers have suggested that within the decade microarrays will be routinely used in the selection, assessment, and quality control of the best drugs for pharmaceutical development, as well as for disease diagnosis and for monitoring desired and adverse outcomes of therapeutic interventions. Realizing this potential will be a challenge for the whole scientific community, as breakthroughs that show great promise at the bench often fail to meet the requirements of clinicians and regulatory scientists. The development of a cooperative framework among regulators, product sponsors, and technology experts will be essential for realizing the revolutionary promise that microarrays hold for drug development, regulatory science, medical practice and public health.
UR - http://www.scopus.com/inward/record.url?scp=0036900945&partnerID=8YFLogxK
U2 - 10.1038/ng1029
DO - 10.1038/ng1029
M3 - Article
C2 - 12454641
AN - SCOPUS:0036900945
SN - 1061-4036
VL - 32
SP - 474
EP - 479
JO - Nature Genetics
JF - Nature Genetics
IS - 4S
ER -