Metals and breast cancer

Celia Byrne; Shailaja D. Divekar; Geoffrey B. Storchan; Daniela A. Parodi; Mary Beth Martin

doi:10.1007/s10911-013-9273-9

Metals and breast cancer

Celia Byrne, Shailaja D. Divekar, Geoffrey B. Storchan, Daniela A. Parodi, Mary Beth Martin^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

160 Scopus citations

Abstract

Metalloestrogens are metals that activate the estrogen receptor in the absence of estradiol. The metalloestrogens fall into two subclasses: metal/metalloid anions and bivalent cationic metals. The metal/metalloid anions include compounds such as arsenite, nitrite, selenite, and vanadate while the bivalent cations include metals such as cadmium, calcium, cobalt, copper, nickel, chromium, lead, mercury, and tin. The best studied metalloestrogen is cadmium. It is a heavy metal and a prevalent environmental contaminant with no known physiological function. This review addresses our current understanding of the mechanism by which cadmium and the bivalent cationic metals activate estrogen receptor-α. The review also summarizes the in vitro and in vivo evidence that cadmium functions as an estrogen and the potential role of cadmium in breast cancer.

Original language	English
Pages (from-to)	63-73
Number of pages	11
Journal	Journal of Mammary Gland Biology and Neoplasia
Volume	18
Issue number	1
DOIs	https://doi.org/10.1007/s10911-013-9273-9
State	Published - Mar 2013
Externally published	Yes

Keywords

Breast cancer
Endocrine disruptors
Estrogen receptor
Estrogens
Metalloestrogens
Metals

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10.1007/s10911-013-9273-9

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title = "Metals and breast cancer",

abstract = "Metalloestrogens are metals that activate the estrogen receptor in the absence of estradiol. The metalloestrogens fall into two subclasses: metal/metalloid anions and bivalent cationic metals. The metal/metalloid anions include compounds such as arsenite, nitrite, selenite, and vanadate while the bivalent cations include metals such as cadmium, calcium, cobalt, copper, nickel, chromium, lead, mercury, and tin. The best studied metalloestrogen is cadmium. It is a heavy metal and a prevalent environmental contaminant with no known physiological function. This review addresses our current understanding of the mechanism by which cadmium and the bivalent cationic metals activate estrogen receptor-α. The review also summarizes the in vitro and in vivo evidence that cadmium functions as an estrogen and the potential role of cadmium in breast cancer.",

keywords = "Breast cancer, Endocrine disruptors, Estrogen receptor, Estrogens, Metalloestrogens, Metals",

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year = "2013",

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AU - Byrne, Celia

AU - Divekar, Shailaja D.

AU - Storchan, Geoffrey B.

AU - Parodi, Daniela A.

AU - Martin, Mary Beth

PY - 2013/3

Y1 - 2013/3

N2 - Metalloestrogens are metals that activate the estrogen receptor in the absence of estradiol. The metalloestrogens fall into two subclasses: metal/metalloid anions and bivalent cationic metals. The metal/metalloid anions include compounds such as arsenite, nitrite, selenite, and vanadate while the bivalent cations include metals such as cadmium, calcium, cobalt, copper, nickel, chromium, lead, mercury, and tin. The best studied metalloestrogen is cadmium. It is a heavy metal and a prevalent environmental contaminant with no known physiological function. This review addresses our current understanding of the mechanism by which cadmium and the bivalent cationic metals activate estrogen receptor-α. The review also summarizes the in vitro and in vivo evidence that cadmium functions as an estrogen and the potential role of cadmium in breast cancer.

AB - Metalloestrogens are metals that activate the estrogen receptor in the absence of estradiol. The metalloestrogens fall into two subclasses: metal/metalloid anions and bivalent cationic metals. The metal/metalloid anions include compounds such as arsenite, nitrite, selenite, and vanadate while the bivalent cations include metals such as cadmium, calcium, cobalt, copper, nickel, chromium, lead, mercury, and tin. The best studied metalloestrogen is cadmium. It is a heavy metal and a prevalent environmental contaminant with no known physiological function. This review addresses our current understanding of the mechanism by which cadmium and the bivalent cationic metals activate estrogen receptor-α. The review also summarizes the in vitro and in vivo evidence that cadmium functions as an estrogen and the potential role of cadmium in breast cancer.

KW - Breast cancer

KW - Endocrine disruptors

KW - Estrogen receptor

KW - Estrogens

KW - Metalloestrogens

KW - Metals

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Metals and breast cancer

Abstract

Keywords

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