@article{f25188dac58a4bfaaa4d280d36a6f314,
title = "Microbiology of combat-related extremity wounds: Trauma Infectious Disease Outcomes Study",
abstract = "We present extremity wound microbiology data from 250 combat casualties (2009–2012). Confirmed extremity wound infections (EWIs)were based on clinical and laboratory findings. Suspected EWIs had isolation of organisms from wound cultures with associated signs/symptoms not meeting clinical diagnostic criteria. Colonized wounds had organisms isolated without any infection suspicion. A total of 335 confirmed EWIs (131 monomicrobial and 204 polymicrobial)were assessed. Gram-negative bacteria were predominant (57% and 86% of monomicrobial and polymicrobial infections, respectively). In polymicrobial infections, 61% grew only bacteria, while 30% isolated bacteria and mold. Multidrug resistance was observed in 32% of isolates from first monomicrobial EWIs ±3 days of diagnosis, while it was 44% of isolates from polymicrobial EWIs. Approximately 96% and 52% of the suspected and colonized wounds, respectively, shared ≥1 organism in common with the confirmed EWI on the same patient. Understanding of combat-related EWIs can lead to improvements in combat casualty care.",
keywords = "Extremity infections, Extremity wounds, Open fractures, Trauma-related infections, Wound microbiology",
author = "Katrin Mende and Laveta Stewart and Faraz Shaikh and William Bradley and Dan Lu and Krauss, {Margot R.} and Lauren Greenberg and Qilu Yu and Blyth, {Dana M.} and Whitman, {Timothy J.} and Petfield, {Joseph L.} and Tribble, {David R.}",
note = "Funding Information: Support for this work (IDCRP-024) was provided by the Infectious Disease Clinical Research Program (IDCRP), a Department of Defense program executed through the Uniformed Services University of the Health Sciences, Department of Preventive Medicine and Biostatistics. This project has been funded by the National Institute of Allergy and Infectious Diseases , National Institutes of Health [under Inter-Agency Agreement Y1-AI-5072], the Department of the Navy under the Wounded, Ill, and Injured Program [grant number HU001–10-0014 ], Defense Medical Research and Development Program [grant number HT9404-12-1-0018 ], and the Military Infectious Diseases Research Program [grant number HU0001-15-2-0045 ]. Funding Information: We are indebted to the Infectious Disease Clinical Research Program Trauma Infectious Disease Outcomes Study team of clinical coordinators, microbiology technicians, data managers, clinical site managers, and administrative support personnel for their tireless hours to ensure the success of this project. Support for this work (IDCRP-024)was provided by the Infectious Disease Clinical Research Program (IDCRP), a Department of Defense program executed through the Uniformed Services University of the Health Sciences, Department of Preventive Medicine and Biostatistics. This project has been funded by the National Institute of Allergy and Infectious Diseases, National Institutes of Health [under Inter-Agency Agreement Y1-AI-5072], the Department of the Navy under the Wounded, Ill, and Injured Program [grant number HU001?10-0014], Defense Medical Research and Development Program [grant number HT9404-12-1-0018], and the Military Infectious Diseases Research Program [grant number HU0001-15-2-0045]. None. The view(s)expressed are those of the authors and do not reflect the official views of the Uniformed Services University of the Health Sciences, Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. the National Institutes of Health or the Department of Health and Human Services, Brooke Army Medical Center, Walter Reed National Military Medical Center, Landstuhl Regional Medical Center, the U.S. Army Medical Department, the U.S. Army Office of the Surgeon General, the Department of Defense, or the Departments of the Army, Navy or Air Force. Mention of trade names, commercial products, or organizations does not imply endorsement by the U.S. Government. Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",
year = "2019",
month = jun,
doi = "10.1016/j.diagmicrobio.2018.12.008",
language = "English",
volume = "94",
pages = "173--179",
journal = "Diagnostic Microbiology and Infectious Disease",
issn = "0732-8893",
number = "2",
}