MicroRNAs as novel biomarkers of deployment status and exposure to polychlorinated dibenzo-p-dioxins/dibenzofurans

Collynn F. Woeller, Thomas H. Thatcher, Daniel Van Twisk, Stephen J. Pollock, Amanda Croasdell, Philip K. Hopke, Xiaoyan Xia, Juilee Thakar, Patricia J. Sime, Timothy M. Mallon, Mark J. Utell, Richard P. Phipps*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Objective: To determine if service members deployed to locations with open air burn pits have different serum microRNA (miRNA) profiles after deployment compared with length-of-service matched, non-deployed individuals. We also tested for correlations between miRNA and serum levels of Polychlorinated Dibenzo-p-Dioxins/Dibenzofurans (PCDD/PCDFs). Methods: MiRNAs were isolated and quantified by PCR array. Groups were analyzed for differences in miRNA expression. Correlations between serum miRNA and PCDD/PCDFs were assessed with a linear regression model. Results: Several miRNAs were differentially expressed after deployment and a partially overlapping set of miRNAs were identified between deployed and non-deployed individuals. Significant correlations between miRNAs and PCDD/PCDFs were identified. Conclusions: Serum miRNA levels show a link between deployment to locations with open burn pits and environmental exposures that can take place during deployment.

Original languageEnglish
Pages (from-to)S89-S96
JournalJournal of Occupational and Environmental Medicine
Issue number8S
StatePublished - 1 Aug 2016
Externally publishedYes


Dive into the research topics of 'MicroRNAs as novel biomarkers of deployment status and exposure to polychlorinated dibenzo-p-dioxins/dibenzofurans'. Together they form a unique fingerprint.

Cite this