MicroRNAs as novel biomarkers of deployment status and exposure to polychlorinated dibenzo-p-dioxins/dibenzofurans

Collynn F. Woeller; Thomas H. Thatcher; Daniel Van Twisk; Stephen J. Pollock; Amanda Croasdell; Philip K. Hopke; Xiaoyan Xia; Juilee Thakar; Patricia J. Sime; Timothy M. Mallon; Mark J. Utell; Richard P. Phipps

doi:10.1097/JOM.0000000000000769

MicroRNAs as novel biomarkers of deployment status and exposure to polychlorinated dibenzo-p-dioxins/dibenzofurans

Collynn F. Woeller, Thomas H. Thatcher, Daniel Van Twisk, Stephen J. Pollock, Amanda Croasdell, Philip K. Hopke, Xiaoyan Xia, Juilee Thakar, Patricia J. Sime, Timothy M. Mallon, Mark J. Utell, Richard P. Phipps^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Objective: To determine if service members deployed to locations with open air burn pits have different serum microRNA (miRNA) profiles after deployment compared with length-of-service matched, non-deployed individuals. We also tested for correlations between miRNA and serum levels of Polychlorinated Dibenzo-p-Dioxins/Dibenzofurans (PCDD/PCDFs). Methods: MiRNAs were isolated and quantified by PCR array. Groups were analyzed for differences in miRNA expression. Correlations between serum miRNA and PCDD/PCDFs were assessed with a linear regression model. Results: Several miRNAs were differentially expressed after deployment and a partially overlapping set of miRNAs were identified between deployed and non-deployed individuals. Significant correlations between miRNAs and PCDD/PCDFs were identified. Conclusions: Serum miRNA levels show a link between deployment to locations with open burn pits and environmental exposures that can take place during deployment.

Original language	English
Pages (from-to)	S89-S96
Journal	Journal of Occupational and Environmental Medicine
Volume	58
Issue number	8S
DOIs	https://doi.org/10.1097/JOM.0000000000000769
State	Published - 1 Aug 2016
Externally published	Yes

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Woeller, C. F., Thatcher, T. H., Van Twisk, D., Pollock, S. J., Croasdell, A., Hopke, P. K., Xia, X., Thakar, J., Sime, P. J., Mallon, T. M., Utell, M. J., & Phipps, R. P. (2016). MicroRNAs as novel biomarkers of deployment status and exposure to polychlorinated dibenzo-p-dioxins/dibenzofurans. Journal of Occupational and Environmental Medicine, 58(8S), S89-S96. https://doi.org/10.1097/JOM.0000000000000769

@article{5d7cefc6ad3a4b9992bdfdc69cea743e,

title = "MicroRNAs as novel biomarkers of deployment status and exposure to polychlorinated dibenzo-p-dioxins/dibenzofurans",

abstract = "Objective: To determine if service members deployed to locations with open air burn pits have different serum microRNA (miRNA) profiles after deployment compared with length-of-service matched, non-deployed individuals. We also tested for correlations between miRNA and serum levels of Polychlorinated Dibenzo-p-Dioxins/Dibenzofurans (PCDD/PCDFs). Methods: MiRNAs were isolated and quantified by PCR array. Groups were analyzed for differences in miRNA expression. Correlations between serum miRNA and PCDD/PCDFs were assessed with a linear regression model. Results: Several miRNAs were differentially expressed after deployment and a partially overlapping set of miRNAs were identified between deployed and non-deployed individuals. Significant correlations between miRNAs and PCDD/PCDFs were identified. Conclusions: Serum miRNA levels show a link between deployment to locations with open burn pits and environmental exposures that can take place during deployment.",

author = "Woeller, {Collynn F.} and Thatcher, {Thomas H.} and {Van Twisk}, Daniel and Pollock, {Stephen J.} and Amanda Croasdell and Hopke, {Philip K.} and Xiaoyan Xia and Juilee Thakar and Sime, {Patricia J.} and Mallon, {Timothy M.} and Utell, {Mark J.} and Phipps, {Richard P.}",

note = "Publisher Copyright: {\textcopyright} 2016 American College of Occupational and Environmental Medicine.",

year = "2016",

month = aug,

day = "1",

doi = "10.1097/JOM.0000000000000769",

language = "English",

volume = "58",

pages = "S89--S96",

journal = "Journal of Occupational and Environmental Medicine",

issn = "1076-2752",

number = "8S",

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Woeller, CF, Thatcher, TH, Van Twisk, D, Pollock, SJ, Croasdell, A, Hopke, PK, Xia, X, Thakar, J, Sime, PJ, Mallon, TM, Utell, MJ & Phipps, RP 2016, 'MicroRNAs as novel biomarkers of deployment status and exposure to polychlorinated dibenzo-p-dioxins/dibenzofurans', Journal of Occupational and Environmental Medicine, vol. 58, no. 8S, pp. S89-S96. https://doi.org/10.1097/JOM.0000000000000769

TY - JOUR

T1 - MicroRNAs as novel biomarkers of deployment status and exposure to polychlorinated dibenzo-p-dioxins/dibenzofurans

AU - Woeller, Collynn F.

AU - Thatcher, Thomas H.

AU - Van Twisk, Daniel

AU - Pollock, Stephen J.

AU - Croasdell, Amanda

AU - Hopke, Philip K.

AU - Xia, Xiaoyan

AU - Thakar, Juilee

AU - Sime, Patricia J.

AU - Mallon, Timothy M.

AU - Utell, Mark J.

AU - Phipps, Richard P.

PY - 2016/8/1

Y1 - 2016/8/1

N2 - Objective: To determine if service members deployed to locations with open air burn pits have different serum microRNA (miRNA) profiles after deployment compared with length-of-service matched, non-deployed individuals. We also tested for correlations between miRNA and serum levels of Polychlorinated Dibenzo-p-Dioxins/Dibenzofurans (PCDD/PCDFs). Methods: MiRNAs were isolated and quantified by PCR array. Groups were analyzed for differences in miRNA expression. Correlations between serum miRNA and PCDD/PCDFs were assessed with a linear regression model. Results: Several miRNAs were differentially expressed after deployment and a partially overlapping set of miRNAs were identified between deployed and non-deployed individuals. Significant correlations between miRNAs and PCDD/PCDFs were identified. Conclusions: Serum miRNA levels show a link between deployment to locations with open burn pits and environmental exposures that can take place during deployment.

AB - Objective: To determine if service members deployed to locations with open air burn pits have different serum microRNA (miRNA) profiles after deployment compared with length-of-service matched, non-deployed individuals. We also tested for correlations between miRNA and serum levels of Polychlorinated Dibenzo-p-Dioxins/Dibenzofurans (PCDD/PCDFs). Methods: MiRNAs were isolated and quantified by PCR array. Groups were analyzed for differences in miRNA expression. Correlations between serum miRNA and PCDD/PCDFs were assessed with a linear regression model. Results: Several miRNAs were differentially expressed after deployment and a partially overlapping set of miRNAs were identified between deployed and non-deployed individuals. Significant correlations between miRNAs and PCDD/PCDFs were identified. Conclusions: Serum miRNA levels show a link between deployment to locations with open burn pits and environmental exposures that can take place during deployment.

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IS - 8S

ER -

MicroRNAs as novel biomarkers of deployment status and exposure to polychlorinated dibenzo-p-dioxins/dibenzofurans

Abstract

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