Microscopic Plasmodium falciparum Gametocytemia and Infectivity to Mosquitoes in Cambodia

Jessica T. Lin; Ratawan Ubalee; Chanthap Lon; Sujata Balasubramanian; Worachet Kuntawunginn; Rifat Rahman; Piyaporn Saingam; Thay Kheang Heng; Dav Vy; Savoeun San; Sarath Nuom; Hana Burkly; Nitima Chanarat; Chanudom Ponsa; Lauren Levitz; Christian Parobek; Char Meng Chuor; Sok Somethy; Michele Spring; Charlotte Lanteri; Panita Gosi; Steven R. Meshnick; David L. Saunders

doi:10.1093/infdis/jiv599

Microscopic Plasmodium falciparum Gametocytemia and Infectivity to Mosquitoes in Cambodia

Jessica T. Lin^*, Ratawan Ubalee, Chanthap Lon, Sujata Balasubramanian, Worachet Kuntawunginn, Rifat Rahman, Piyaporn Saingam, Thay Kheang Heng, Dav Vy, Savoeun San, Sarath Nuom, Hana Burkly, Nitima Chanarat, Chanudom Ponsa, Lauren Levitz, Christian Parobek, Char Meng Chuor, Sok Somethy, Michele Spring, Charlotte LanteriPanita Gosi, Steven R. Meshnick, David L. Saunders

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

Although gametocytes are essential for malaria transmission, in Africa many falciparum-infected persons without smear-detectable gametocytes still infect mosquitoes. To see whether the same is true in Southeast Asia, we determined the infectiousness of 119 falciparum-infected Cambodian adults to Anopheles dirus mosquitoes by membrane feeding. Just 5.9% of subjects infected mosquitoes. The 8.4% of patients with smear-detectable gametocytes were >20 times more likely to infect mosquitoes than those without and were the source of 96% of all mosquito infections. In low-transmission settings, targeting transmission-blocking interventions to those with microscopic gametocytemia may have an outsized effect on malaria control and elimination.

Original language	English
Pages (from-to)	1491-1494
Number of pages	4
Journal	Journal of Infectious Diseases
Volume	213
Issue number	9
DOIs	https://doi.org/10.1093/infdis/jiv599
State	Published - 1 May 2016
Externally published	Yes

Keywords

Anopheles dirus
Plasmodium falciparum
gametocyte membrane feeding
infectious reservoir
malaria transmission
submicroscopic

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10.1093/infdis/jiv599

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Lin, J. T., Ubalee, R., Lon, C., Balasubramanian, S., Kuntawunginn, W., Rahman, R., Saingam, P., Heng, T. K., Vy, D., San, S., Nuom, S., Burkly, H., Chanarat, N., Ponsa, C., Levitz, L., Parobek, C., Chuor, C. M., Somethy, S., Spring, M., ... Saunders, D. L. (2016). Microscopic Plasmodium falciparum Gametocytemia and Infectivity to Mosquitoes in Cambodia. Journal of Infectious Diseases, 213(9), 1491-1494. https://doi.org/10.1093/infdis/jiv599

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title = "Microscopic Plasmodium falciparum Gametocytemia and Infectivity to Mosquitoes in Cambodia",

abstract = "Although gametocytes are essential for malaria transmission, in Africa many falciparum-infected persons without smear-detectable gametocytes still infect mosquitoes. To see whether the same is true in Southeast Asia, we determined the infectiousness of 119 falciparum-infected Cambodian adults to Anopheles dirus mosquitoes by membrane feeding. Just 5.9% of subjects infected mosquitoes. The 8.4% of patients with smear-detectable gametocytes were >20 times more likely to infect mosquitoes than those without and were the source of 96% of all mosquito infections. In low-transmission settings, targeting transmission-blocking interventions to those with microscopic gametocytemia may have an outsized effect on malaria control and elimination.",

keywords = "Anopheles dirus, Plasmodium falciparum, gametocyte membrane feeding, infectious reservoir, malaria transmission, submicroscopic",

author = "Lin, {Jessica T.} and Ratawan Ubalee and Chanthap Lon and Sujata Balasubramanian and Worachet Kuntawunginn and Rifat Rahman and Piyaporn Saingam and Heng, {Thay Kheang} and Dav Vy and Savoeun San and Sarath Nuom and Hana Burkly and Nitima Chanarat and Chanudom Ponsa and Lauren Levitz and Christian Parobek and Chuor, {Char Meng} and Sok Somethy and Michele Spring and Charlotte Lanteri and Panita Gosi and Meshnick, {Steven R.} and Saunders, {David L.}",

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Lin, JT, Ubalee, R, Lon, C, Balasubramanian, S, Kuntawunginn, W, Rahman, R, Saingam, P, Heng, TK, Vy, D, San, S, Nuom, S, Burkly, H, Chanarat, N, Ponsa, C, Levitz, L, Parobek, C, Chuor, CM, Somethy, S, Spring, M, Lanteri, C, Gosi, P, Meshnick, SR & Saunders, DL 2016, 'Microscopic Plasmodium falciparum Gametocytemia and Infectivity to Mosquitoes in Cambodia', Journal of Infectious Diseases, vol. 213, no. 9, pp. 1491-1494. https://doi.org/10.1093/infdis/jiv599

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T1 - Microscopic Plasmodium falciparum Gametocytemia and Infectivity to Mosquitoes in Cambodia

AU - Lin, Jessica T.

AU - Ubalee, Ratawan

AU - Lon, Chanthap

AU - Balasubramanian, Sujata

AU - Kuntawunginn, Worachet

AU - Rahman, Rifat

AU - Saingam, Piyaporn

AU - Heng, Thay Kheang

AU - Vy, Dav

AU - San, Savoeun

AU - Nuom, Sarath

AU - Burkly, Hana

AU - Chanarat, Nitima

AU - Ponsa, Chanudom

AU - Levitz, Lauren

AU - Parobek, Christian

AU - Chuor, Char Meng

AU - Somethy, Sok

AU - Spring, Michele

AU - Lanteri, Charlotte

AU - Gosi, Panita

AU - Meshnick, Steven R.

AU - Saunders, David L.

PY - 2016/5/1

Y1 - 2016/5/1

N2 - Although gametocytes are essential for malaria transmission, in Africa many falciparum-infected persons without smear-detectable gametocytes still infect mosquitoes. To see whether the same is true in Southeast Asia, we determined the infectiousness of 119 falciparum-infected Cambodian adults to Anopheles dirus mosquitoes by membrane feeding. Just 5.9% of subjects infected mosquitoes. The 8.4% of patients with smear-detectable gametocytes were >20 times more likely to infect mosquitoes than those without and were the source of 96% of all mosquito infections. In low-transmission settings, targeting transmission-blocking interventions to those with microscopic gametocytemia may have an outsized effect on malaria control and elimination.

AB - Although gametocytes are essential for malaria transmission, in Africa many falciparum-infected persons without smear-detectable gametocytes still infect mosquitoes. To see whether the same is true in Southeast Asia, we determined the infectiousness of 119 falciparum-infected Cambodian adults to Anopheles dirus mosquitoes by membrane feeding. Just 5.9% of subjects infected mosquitoes. The 8.4% of patients with smear-detectable gametocytes were >20 times more likely to infect mosquitoes than those without and were the source of 96% of all mosquito infections. In low-transmission settings, targeting transmission-blocking interventions to those with microscopic gametocytemia may have an outsized effect on malaria control and elimination.

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KW - Plasmodium falciparum

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KW - infectious reservoir

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JO - Journal of Infectious Diseases

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IS - 9

ER -

Microscopic Plasmodium falciparum Gametocytemia and Infectivity to Mosquitoes in Cambodia

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Keywords

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