Migraine and MTHFR C677T genotype in a population-based sample

Ann I. Scher*, Gisela M. Terwindt, W. M.Monique Verschuren, Mark C. Kruit, Henk J. Blom, Hisanori Kowa, Rune R. Frants, Arn M.J.M. Van Den Maagdenberg, Mark Van Buchem, Michel D. Ferrari, Lenore J. Launer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

183 Scopus citations

Abstract

Objective: Migraine with aura is associated with increased risk of stroke. The MTHFR C677T genotype has been associated with increased risk of migraine in selected clinical samples and with elevated homocysteine, a risk factor for stroke. We assessed the association of the MTHFR C677T variant with migraine and the mediating effect of cardiovascular risk factors and metabolic markers of genotype status. Methods: We compared adult migraineurs with aura (MA; n = 187), without aura (MO; n = 226), and nonmigraineurs (n = 1,212) from the population-based Genetic Epidemiology of Migraine study. Results: Compared with the wild-type genotype, the T/T genotype was associated with increased odds of MA (odds ratio [OR], 2.05; 95% confidence interval, 1.2-3.4; p < 0.006), with a trend of increasing numbers of T alleles (OR, 1.40; 95% confidence interval, 1.1-1.8; p < 0.007). ORs were slightly attenuated after adjusting for homocysteine. Interpretation: Risk of MA is associated with MTHFR C674T homozygosity, independent of other cardiovascular risk factors.

Original languageEnglish
Pages (from-to)372-375
Number of pages4
JournalAnnals of Neurology
Volume59
Issue number2
DOIs
StatePublished - Feb 2006
Externally publishedYes

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