Migraine and MTHFR C677T genotype in a population-based sample

Ann I. Scher; Gisela M. Terwindt; W. M.Monique Verschuren; Mark C. Kruit; Henk J. Blom; Hisanori Kowa; Rune R. Frants; Arn M.J.M. Van Den Maagdenberg; Mark Van Buchem; Michel D. Ferrari; Lenore J. Launer

doi:10.1002/ana.20755

Migraine and MTHFR C677T genotype in a population-based sample

Ann I. Scher^*, Gisela M. Terwindt, W. M.Monique Verschuren, Mark C. Kruit, Henk J. Blom, Hisanori Kowa, Rune R. Frants, Arn M.J.M. Van Den Maagdenberg, Mark Van Buchem, Michel D. Ferrari, Lenore J. Launer

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

185 Scopus citations

Abstract

Objective: Migraine with aura is associated with increased risk of stroke. The MTHFR C677T genotype has been associated with increased risk of migraine in selected clinical samples and with elevated homocysteine, a risk factor for stroke. We assessed the association of the MTHFR C677T variant with migraine and the mediating effect of cardiovascular risk factors and metabolic markers of genotype status. Methods: We compared adult migraineurs with aura (MA; n = 187), without aura (MO; n = 226), and nonmigraineurs (n = 1,212) from the population-based Genetic Epidemiology of Migraine study. Results: Compared with the wild-type genotype, the T/T genotype was associated with increased odds of MA (odds ratio [OR], 2.05; 95% confidence interval, 1.2-3.4; p < 0.006), with a trend of increasing numbers of T alleles (OR, 1.40; 95% confidence interval, 1.1-1.8; p < 0.007). ORs were slightly attenuated after adjusting for homocysteine. Interpretation: Risk of MA is associated with MTHFR C674T homozygosity, independent of other cardiovascular risk factors.

Original language	English
Pages (from-to)	372-375
Number of pages	4
Journal	Annals of Neurology
Volume	59
Issue number	2
DOIs	https://doi.org/10.1002/ana.20755
State	Published - Feb 2006
Externally published	Yes

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@article{dfca63968e8349b88160aba2d3957097,

title = "Migraine and MTHFR C677T genotype in a population-based sample",

abstract = "Objective: Migraine with aura is associated with increased risk of stroke. The MTHFR C677T genotype has been associated with increased risk of migraine in selected clinical samples and with elevated homocysteine, a risk factor for stroke. We assessed the association of the MTHFR C677T variant with migraine and the mediating effect of cardiovascular risk factors and metabolic markers of genotype status. Methods: We compared adult migraineurs with aura (MA; n = 187), without aura (MO; n = 226), and nonmigraineurs (n = 1,212) from the population-based Genetic Epidemiology of Migraine study. Results: Compared with the wild-type genotype, the T/T genotype was associated with increased odds of MA (odds ratio [OR], 2.05; 95% confidence interval, 1.2-3.4; p < 0.006), with a trend of increasing numbers of T alleles (OR, 1.40; 95% confidence interval, 1.1-1.8; p < 0.007). ORs were slightly attenuated after adjusting for homocysteine. Interpretation: Risk of MA is associated with MTHFR C674T homozygosity, independent of other cardiovascular risk factors.",

author = "Scher, {Ann I.} and Terwindt, {Gisela M.} and Verschuren, {W. M.Monique} and Kruit, {Mark C.} and Blom, {Henk J.} and Hisanori Kowa and Frants, {Rune R.} and {Van Den Maagdenberg}, {Arn M.J.M.} and {Van Buchem}, Mark and Ferrari, {Michel D.} and Launer, {Lenore J.}",

year = "2006",

month = feb,

doi = "10.1002/ana.20755",

language = "English",

volume = "59",

pages = "372--375",

journal = "Annals of Neurology",

issn = "0364-5134",

number = "2",

}

TY - JOUR

T1 - Migraine and MTHFR C677T genotype in a population-based sample

AU - Scher, Ann I.

AU - Terwindt, Gisela M.

AU - Verschuren, W. M.Monique

AU - Kruit, Mark C.

AU - Blom, Henk J.

AU - Kowa, Hisanori

AU - Frants, Rune R.

AU - Van Den Maagdenberg, Arn M.J.M.

AU - Van Buchem, Mark

AU - Ferrari, Michel D.

AU - Launer, Lenore J.

PY - 2006/2

Y1 - 2006/2

N2 - Objective: Migraine with aura is associated with increased risk of stroke. The MTHFR C677T genotype has been associated with increased risk of migraine in selected clinical samples and with elevated homocysteine, a risk factor for stroke. We assessed the association of the MTHFR C677T variant with migraine and the mediating effect of cardiovascular risk factors and metabolic markers of genotype status. Methods: We compared adult migraineurs with aura (MA; n = 187), without aura (MO; n = 226), and nonmigraineurs (n = 1,212) from the population-based Genetic Epidemiology of Migraine study. Results: Compared with the wild-type genotype, the T/T genotype was associated with increased odds of MA (odds ratio [OR], 2.05; 95% confidence interval, 1.2-3.4; p < 0.006), with a trend of increasing numbers of T alleles (OR, 1.40; 95% confidence interval, 1.1-1.8; p < 0.007). ORs were slightly attenuated after adjusting for homocysteine. Interpretation: Risk of MA is associated with MTHFR C674T homozygosity, independent of other cardiovascular risk factors.

AB - Objective: Migraine with aura is associated with increased risk of stroke. The MTHFR C677T genotype has been associated with increased risk of migraine in selected clinical samples and with elevated homocysteine, a risk factor for stroke. We assessed the association of the MTHFR C677T variant with migraine and the mediating effect of cardiovascular risk factors and metabolic markers of genotype status. Methods: We compared adult migraineurs with aura (MA; n = 187), without aura (MO; n = 226), and nonmigraineurs (n = 1,212) from the population-based Genetic Epidemiology of Migraine study. Results: Compared with the wild-type genotype, the T/T genotype was associated with increased odds of MA (odds ratio [OR], 2.05; 95% confidence interval, 1.2-3.4; p < 0.006), with a trend of increasing numbers of T alleles (OR, 1.40; 95% confidence interval, 1.1-1.8; p < 0.007). ORs were slightly attenuated after adjusting for homocysteine. Interpretation: Risk of MA is associated with MTHFR C674T homozygosity, independent of other cardiovascular risk factors.

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U2 - 10.1002/ana.20755

DO - 10.1002/ana.20755

M3 - Article

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AN - SCOPUS:32044450821

SN - 0364-5134

VL - 59

SP - 372

EP - 375

JO - Annals of Neurology

JF - Annals of Neurology

IS - 2

ER -

Migraine and MTHFR C677T genotype in a population-based sample

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