Mitochondria-Targeted Antioxidant Therapeutics for Traumatic Brain Injury

Hiren R. Modi, Sudeep Musyaju, Meaghan Ratcliffe, Deborah A. Shear, Anke H. Scultetus, Jignesh D. Pandya*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Traumatic brain injury (TBI) is a major global health problem that affects both civilian and military populations worldwide. Post-injury acute, sub-acute, and chronic progression of secondary injury processes may contribute further to other neurodegenerative diseases. However, there are no approved therapeutic options available that can attenuate TBI-related progressive pathophysiology. Recent advances in preclinical research have identified that mitochondria-centric redox imbalance, bioenergetics failure and calcium dysregulation play a crucial role in secondary injury progression after TBI. Mitochondrial antioxidants play an important role in regulating redox homeostasis. Based on the proven efficacy of preclinical and clinical compounds and targeting numerous pathways to trigger innate antioxidant defense, we may be able to alleviate TBI pathology progression by primarily focusing on preserving post-injury mitochondrial and cerebral function. In this review, we will discuss novel mitochondria-targeted antioxidant compounds, which offer a high capability of successful clinical translation for TBI management in the near future.

Original languageEnglish
Article number303
JournalAntioxidants
Volume13
Issue number3
DOIs
StatePublished - Mar 2024
Externally publishedYes

Keywords

  • antioxidants
  • cell death
  • free radicals
  • mitochondria
  • neuroprotection
  • oxidative stress
  • therapeutics
  • traumatic brain injury

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