Abstract
Mitochondrial disorders arise from DNA mutations in either the mitochondrial DNA (mtDNA) or nuclear DNA genomes. This article focuses on a mtDNA base-pair mutation associated with neuropathy, ataxia, and retinitis pigmentosa and Leigh syndrome and the large-scale mtDNA deletion associated with Kearns-Sayre syndrome. Disease sequelae and management strategies are reviewed, along with implications for the nurse practitioner in primary or specialty care.
| Original language | English |
|---|---|
| Pages (from-to) | 954-956 |
| Number of pages | 3 |
| Journal | Journal of the American Association of Nurse Practitioners |
| Volume | 34 |
| Issue number | 8 |
| DOIs | |
| State | Published - 5 Aug 2022 |
| Externally published | Yes |
Keywords
- DNA
- Kearns-Sayre Syndrome
- Leigh disease
- NARP syndrome
- mitochondrial
- mitochondrial diseases
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