Modeling host-vector-pathogen immuno-inflammatory interactions in malaria

Yoram Vodovotz, Nabil Azhar*, Natasa Miskov-Zivanov, Marius Buliga, Ruben Zamora, Bard Ermentrout, Gregory M. Constantine, James R. Faeder, Nazzy Pakpour, Shirley Luckhart

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

2 Scopus citations


Half of the global population is at risk for malaria, which results in nearly one million deaths annually, 86 % of which are in children [1]. Plasmodium falciparum, the most important human malaria parasite, is transmitted by female Anopheles mosquitoes. Parasite development in the mosquito begins with the ingestion of blood containing sexualstage gametocytes. Mobile ookinetes penetrate the midgut epithelium 24-36 h later and transform into midgut-bound oocysts within the open circulatory system of the mosquito. Oocysts grow and develop for 10-12 days and then release thousands of sporozoites, which invade the salivary glands and are released during later blood feeding by the mosquito.

Original languageEnglish
Title of host publicationComplex Systems and Computational Biology Approaches to Acute Inflammation
PublisherSpringer New York
Number of pages15
ISBN (Electronic)9781461480082
ISBN (Print)1461480078, 9781461480075
StatePublished - 1 May 2013
Externally publishedYes


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