Modeling host-vector-pathogen immuno-inflammatory interactions in malaria

Yoram Vodovotz; Nabil Azhar; Natasa Miskov-Zivanov; Marius Buliga; Ruben Zamora; Bard Ermentrout; Gregory M. Constantine; James R. Faeder; Nazzy Pakpour; Shirley Luckhart

doi:10.1007/978-1-4614-8008-2_14

Modeling host-vector-pathogen immuno-inflammatory interactions in malaria

Yoram Vodovotz, Nabil Azhar^*, Natasa Miskov-Zivanov, Marius Buliga, Ruben Zamora, Bard Ermentrout, Gregory M. Constantine, James R. Faeder, Nazzy Pakpour, Shirley Luckhart

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

2 Scopus citations

Abstract

Half of the global population is at risk for malaria, which results in nearly one million deaths annually, 86 % of which are in children [1]. Plasmodium falciparum, the most important human malaria parasite, is transmitted by female Anopheles mosquitoes. Parasite development in the mosquito begins with the ingestion of blood containing sexualstage gametocytes. Mobile ookinetes penetrate the midgut epithelium 24-36 h later and transform into midgut-bound oocysts within the open circulatory system of the mosquito. Oocysts grow and develop for 10-12 days and then release thousands of sporozoites, which invade the salivary glands and are released during later blood feeding by the mosquito.

Original language	English
Title of host publication	Complex Systems and Computational Biology Approaches to Acute Inflammation
Publisher	Springer New York
Pages	265-279
Number of pages	15
Volume	9781461480082
ISBN (Electronic)	9781461480082
ISBN (Print)	1461480078, 9781461480075
DOIs	https://doi.org/10.1007/978-1-4614-8008-2_14
State	Published - 1 May 2013
Externally published	Yes

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Vodovotz, Y., Azhar, N., Miskov-Zivanov, N., Buliga, M., Zamora, R., Ermentrout, B., Constantine, G. M., Faeder, J. R., Pakpour, N., & Luckhart, S. (2013). Modeling host-vector-pathogen immuno-inflammatory interactions in malaria. In Complex Systems and Computational Biology Approaches to Acute Inflammation (Vol. 9781461480082, pp. 265-279). Springer New York. https://doi.org/10.1007/978-1-4614-8008-2_14

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abstract = "Half of the global population is at risk for malaria, which results in nearly one million deaths annually, 86 % of which are in children [1]. Plasmodium falciparum, the most important human malaria parasite, is transmitted by female Anopheles mosquitoes. Parasite development in the mosquito begins with the ingestion of blood containing sexualstage gametocytes. Mobile ookinetes penetrate the midgut epithelium 24-36 h later and transform into midgut-bound oocysts within the open circulatory system of the mosquito. Oocysts grow and develop for 10-12 days and then release thousands of sporozoites, which invade the salivary glands and are released during later blood feeding by the mosquito.",

author = "Yoram Vodovotz and Nabil Azhar and Natasa Miskov-Zivanov and Marius Buliga and Ruben Zamora and Bard Ermentrout and Constantine, {Gregory M.} and Faeder, {James R.} and Nazzy Pakpour and Shirley Luckhart",

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Vodovotz, Y, Azhar, N, Miskov-Zivanov, N, Buliga, M, Zamora, R, Ermentrout, B, Constantine, GM, Faeder, JR, Pakpour, N & Luckhart, S 2013, Modeling host-vector-pathogen immuno-inflammatory interactions in malaria. in Complex Systems and Computational Biology Approaches to Acute Inflammation. vol. 9781461480082, Springer New York, pp. 265-279. https://doi.org/10.1007/978-1-4614-8008-2_14

TY - CHAP

T1 - Modeling host-vector-pathogen immuno-inflammatory interactions in malaria

AU - Vodovotz, Yoram

AU - Azhar, Nabil

AU - Miskov-Zivanov, Natasa

AU - Buliga, Marius

AU - Zamora, Ruben

AU - Ermentrout, Bard

AU - Constantine, Gregory M.

AU - Faeder, James R.

AU - Pakpour, Nazzy

AU - Luckhart, Shirley

PY - 2013/5/1

Y1 - 2013/5/1

N2 - Half of the global population is at risk for malaria, which results in nearly one million deaths annually, 86 % of which are in children [1]. Plasmodium falciparum, the most important human malaria parasite, is transmitted by female Anopheles mosquitoes. Parasite development in the mosquito begins with the ingestion of blood containing sexualstage gametocytes. Mobile ookinetes penetrate the midgut epithelium 24-36 h later and transform into midgut-bound oocysts within the open circulatory system of the mosquito. Oocysts grow and develop for 10-12 days and then release thousands of sporozoites, which invade the salivary glands and are released during later blood feeding by the mosquito.

AB - Half of the global population is at risk for malaria, which results in nearly one million deaths annually, 86 % of which are in children [1]. Plasmodium falciparum, the most important human malaria parasite, is transmitted by female Anopheles mosquitoes. Parasite development in the mosquito begins with the ingestion of blood containing sexualstage gametocytes. Mobile ookinetes penetrate the midgut epithelium 24-36 h later and transform into midgut-bound oocysts within the open circulatory system of the mosquito. Oocysts grow and develop for 10-12 days and then release thousands of sporozoites, which invade the salivary glands and are released during later blood feeding by the mosquito.

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U2 - 10.1007/978-1-4614-8008-2_14

DO - 10.1007/978-1-4614-8008-2_14

M3 - Chapter

AN - SCOPUS:84879871357

SN - 1461480078

SN - 9781461480075

VL - 9781461480082

SP - 265

EP - 279

BT - Complex Systems and Computational Biology Approaches to Acute Inflammation

PB - Springer New York

ER -

Modeling host-vector-pathogen immuno-inflammatory interactions in malaria

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