Modelling traumatic brain injury and posttraumatic epilepsy in rodents

Rhys D. Brady; Pablo M. Casillas-Espinosa; Denes V. Agoston; Edward H. Bertram; Alaa Kamnaksh; Bridgette D. Semple; Sandy R. Shultz

doi:10.1016/j.nbd.2018.08.007

Modelling traumatic brain injury and posttraumatic epilepsy in rodents

Rhys D. Brady^*, Pablo M. Casillas-Espinosa, Denes V. Agoston, Edward H. Bertram, Alaa Kamnaksh, Bridgette D. Semple, Sandy R. Shultz

^*Corresponding author for this work

Anatomy, Physiology, and Genetics

Research output: Contribution to journal › Review article › peer-review

55 Scopus citations

Abstract

Posttraumatic epilepsy (PTE) is one of the most debilitating and understudied consequences of traumatic brain injury (TBI). It is challenging to study the effects, underlying pathophysiology, biomarkers, and treatment of TBI and PTE purely in human patients for a number of reasons. Rodent models can complement human PTE studies as they allow for the rigorous investigation into the causal relationship between TBI and PTE, the pathophysiological mechanisms of PTE, the validation and implementation of PTE biomarkers, and the assessment of PTE treatments, in a tightly controlled, time- and cost-efficient manner in experimental subjects known to be experiencing epileptogenic processes. This article will review several common rodent models of TBI and/or PTE, including their use in previous studies and discuss their relative strengths, limitations, and avenues for future research to advance our understanding and treatment of PTE.

Original language	English
Pages (from-to)	8-19
Number of pages	12
Journal	Neurobiology of Disease
Volume	123
DOIs	https://doi.org/10.1016/j.nbd.2018.08.007
State	Published - Mar 2019

Keywords

Posttraumatic epilepsy
Review
Translational research
Traumatic brain injury

Access to Document

10.1016/j.nbd.2018.08.007

Cite this

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title = "Modelling traumatic brain injury and posttraumatic epilepsy in rodents",

abstract = "Posttraumatic epilepsy (PTE) is one of the most debilitating and understudied consequences of traumatic brain injury (TBI). It is challenging to study the effects, underlying pathophysiology, biomarkers, and treatment of TBI and PTE purely in human patients for a number of reasons. Rodent models can complement human PTE studies as they allow for the rigorous investigation into the causal relationship between TBI and PTE, the pathophysiological mechanisms of PTE, the validation and implementation of PTE biomarkers, and the assessment of PTE treatments, in a tightly controlled, time- and cost-efficient manner in experimental subjects known to be experiencing epileptogenic processes. This article will review several common rodent models of TBI and/or PTE, including their use in previous studies and discuss their relative strengths, limitations, and avenues for future research to advance our understanding and treatment of PTE.",

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AU - Casillas-Espinosa, Pablo M.

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AU - Kamnaksh, Alaa

AU - Semple, Bridgette D.

AU - Shultz, Sandy R.

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