Modulation of blood fluke development in the liver by hepatic CD4+ lymphocytes

S. J. Davies; J. L. Grogan; R. B. Blank; K. C. Lim; R. M. Locksley; J. H. McKerrow

doi:10.1126/science.1064462

Modulation of blood fluke development in the liver by hepatic CD4⁺ lymphocytes

S. J. Davies, J. L. Grogan, R. B. Blank, K. C. Lim, R. M. Locksley, J. H. McKerrow^*

^*Corresponding author for this work

Preventive Medicine and Biostatistics

Research output: Contribution to journal › Article › peer-review

134 Scopus citations

Abstract

We have identified an alternate developmental pathway in the life cycle of the trematode pathogen Schistosoma mansoni. This pathway is used in immunodeficient hosts in which the parasite fails to receive appropriate signals from the host immune system. Helminth development is altered at an early stage during infection, resulting in the appearance of attenuated forms that prolong survival of host and parasite. Hepatic CD4⁺ T lymphocyte populations are an integral component of the immune signal recognized by the parasite.

Original language	English
Pages (from-to)	1358-1361
Number of pages	4
Journal	Science
Volume	294
Issue number	5545
DOIs	https://doi.org/10.1126/science.1064462
State	Published - 9 Nov 2001

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abstract = "We have identified an alternate developmental pathway in the life cycle of the trematode pathogen Schistosoma mansoni. This pathway is used in immunodeficient hosts in which the parasite fails to receive appropriate signals from the host immune system. Helminth development is altered at an early stage during infection, resulting in the appearance of attenuated forms that prolong survival of host and parasite. Hepatic CD4+ T lymphocyte populations are an integral component of the immune signal recognized by the parasite.",

author = "Davies, {S. J.} and Grogan, {J. L.} and Blank, {R. B.} and Lim, {K. C.} and Locksley, {R. M.} and McKerrow, {J. H.}",

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AU - Locksley, R. M.

AU - McKerrow, J. H.

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AB - We have identified an alternate developmental pathway in the life cycle of the trematode pathogen Schistosoma mansoni. This pathway is used in immunodeficient hosts in which the parasite fails to receive appropriate signals from the host immune system. Helminth development is altered at an early stage during infection, resulting in the appearance of attenuated forms that prolong survival of host and parasite. Hepatic CD4+ T lymphocyte populations are an integral component of the immune signal recognized by the parasite.

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Modulation of blood fluke development in the liver by hepatic CD4+ lymphocytes

Abstract

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Modulation of blood fluke development in the liver by hepatic CD4⁺ lymphocytes