Modulation of blood fluke development in the liver by hepatic CD4+ lymphocytes

S. J. Davies, J. L. Grogan, R. B. Blank, K. C. Lim, R. M. Locksley, J. H. McKerrow*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

133 Scopus citations

Abstract

We have identified an alternate developmental pathway in the life cycle of the trematode pathogen Schistosoma mansoni. This pathway is used in immunodeficient hosts in which the parasite fails to receive appropriate signals from the host immune system. Helminth development is altered at an early stage during infection, resulting in the appearance of attenuated forms that prolong survival of host and parasite. Hepatic CD4+ T lymphocyte populations are an integral component of the immune signal recognized by the parasite.

Original languageEnglish
Pages (from-to)1358-1361
Number of pages4
JournalScience
Volume294
Issue number5545
DOIs
StatePublished - 9 Nov 2001

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