TY - JOUR
T1 - Modulation of protein expression and activity by radiation
T2 - Relevance to intracoronary radiation for the prevention of restenosis
AU - Vodovotz, Yoram
AU - Mitchell, James B.
AU - Lucia, M. Scott
AU - McKinney, Leslie
AU - Kollum, Marc
AU - Cottin, Yves
AU - Chan, Rosanna C.
AU - Barcellos-Hoff, Mary Helen
AU - Waksman, Ron
PY - 1999/10
Y1 - 1999/10
N2 - Restenosis is a common complication of percutaneous transluminal coronary angioplasty. Recent studies have demonstrated a striking reduction in the neointimal hyperplasia characteristic of restenosis following intracoronary radiation (IR), but the mechanisms by which radiation reduces neointima formation following balloon overstretch injury are not elucidated fully. In addition to direct antimitotic effects mediated via oxygen free radicals, ionizing radiation can induce the expression of numerous genes and thereby mediate indirect effects. Additionally, IR prevents restenosis at the cost of decreased healing and increased thrombosis, and we suggest that these adverse reactions can be modulated by adjunct pharmacology or gene-based strategies. This review discusses several genes and proteins modulated by radiation in the context of arterial injury, and their possible therapeutic relevance.
AB - Restenosis is a common complication of percutaneous transluminal coronary angioplasty. Recent studies have demonstrated a striking reduction in the neointimal hyperplasia characteristic of restenosis following intracoronary radiation (IR), but the mechanisms by which radiation reduces neointima formation following balloon overstretch injury are not elucidated fully. In addition to direct antimitotic effects mediated via oxygen free radicals, ionizing radiation can induce the expression of numerous genes and thereby mediate indirect effects. Additionally, IR prevents restenosis at the cost of decreased healing and increased thrombosis, and we suggest that these adverse reactions can be modulated by adjunct pharmacology or gene-based strategies. This review discusses several genes and proteins modulated by radiation in the context of arterial injury, and their possible therapeutic relevance.
KW - Latency-associated peptide (LAP)
KW - Nitric oxide (NO)
KW - Nitric oxide synthase
KW - Telomerase
KW - Terminal deoxynucleotidyl transferase (TUNEL)
KW - Thrombosis
KW - Transforming growth factor-β1 (TGF-β1)
UR - http://www.scopus.com/inward/record.url?scp=0033207018&partnerID=8YFLogxK
U2 - 10.1016/S1522-1865(00)00026-3
DO - 10.1016/S1522-1865(00)00026-3
M3 - Article
C2 - 10828563
AN - SCOPUS:0033207018
SN - 1522-1865
VL - 1
SP - 336
EP - 343
JO - Cardiovascular Radiation Medicine
JF - Cardiovascular Radiation Medicine
IS - 4
ER -