Modulation of protein expression and activity by radiation: Relevance to intracoronary radiation for the prevention of restenosis

Yoram Vodovotz; James B. Mitchell; M. Scott Lucia; Leslie McKinney; Marc Kollum; Yves Cottin; Rosanna C. Chan; Mary Helen Barcellos-Hoff; Ron Waksman

doi:10.1016/S1522-1865(00)00026-3

Modulation of protein expression and activity by radiation: Relevance to intracoronary radiation for the prevention of restenosis

Yoram Vodovotz^*
, James B. Mitchell
, M. Scott Lucia
, Leslie McKinney
, Marc Kollum
, Yves Cottin
, Rosanna C. Chan
, Mary Helen Barcellos-Hoff
, Ron Waksman

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Restenosis is a common complication of percutaneous transluminal coronary angioplasty. Recent studies have demonstrated a striking reduction in the neointimal hyperplasia characteristic of restenosis following intracoronary radiation (IR), but the mechanisms by which radiation reduces neointima formation following balloon overstretch injury are not elucidated fully. In addition to direct antimitotic effects mediated via oxygen free radicals, ionizing radiation can induce the expression of numerous genes and thereby mediate indirect effects. Additionally, IR prevents restenosis at the cost of decreased healing and increased thrombosis, and we suggest that these adverse reactions can be modulated by adjunct pharmacology or gene-based strategies. This review discusses several genes and proteins modulated by radiation in the context of arterial injury, and their possible therapeutic relevance.

Original language	English
Pages (from-to)	336-343
Number of pages	8
Journal	Cardiovascular Radiation Medicine
Volume	1
Issue number	4
DOIs	https://doi.org/10.1016/S1522-1865(00)00026-3
State	Published - Oct 1999
Externally published	Yes

Keywords

Latency-associated peptide (LAP)
Nitric oxide (NO)
Nitric oxide synthase
Telomerase
Terminal deoxynucleotidyl transferase (TUNEL)
Thrombosis
Transforming growth factor-β1 (TGF-β1)

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10.1016/S1522-1865(00)00026-3

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@article{a2efab9d2a46487babc783e5793107c7,

title = "Modulation of protein expression and activity by radiation: Relevance to intracoronary radiation for the prevention of restenosis",

abstract = "Restenosis is a common complication of percutaneous transluminal coronary angioplasty. Recent studies have demonstrated a striking reduction in the neointimal hyperplasia characteristic of restenosis following intracoronary radiation (IR), but the mechanisms by which radiation reduces neointima formation following balloon overstretch injury are not elucidated fully. In addition to direct antimitotic effects mediated via oxygen free radicals, ionizing radiation can induce the expression of numerous genes and thereby mediate indirect effects. Additionally, IR prevents restenosis at the cost of decreased healing and increased thrombosis, and we suggest that these adverse reactions can be modulated by adjunct pharmacology or gene-based strategies. This review discusses several genes and proteins modulated by radiation in the context of arterial injury, and their possible therapeutic relevance.",

keywords = "Latency-associated peptide (LAP), Nitric oxide (NO), Nitric oxide synthase, Telomerase, Terminal deoxynucleotidyl transferase (TUNEL), Thrombosis, Transforming growth factor-β1 (TGF-β1)",

author = "Yoram Vodovotz and Mitchell, \{James B.\} and Lucia, \{M. Scott\} and Leslie McKinney and Marc Kollum and Yves Cottin and Chan, \{Rosanna C.\} and Barcellos-Hoff, \{Mary Helen\} and Ron Waksman",

year = "1999",

month = oct,

doi = "10.1016/S1522-1865(00)00026-3",

language = "English",

volume = "1",

pages = "336--343",

journal = "Cardiovascular Radiation Medicine",

issn = "1522-1865",

publisher = "Elsevier B.V.",

number = "4",

}

TY - JOUR

T1 - Modulation of protein expression and activity by radiation

T2 - Relevance to intracoronary radiation for the prevention of restenosis

AU - Vodovotz, Yoram

AU - Mitchell, James B.

AU - Lucia, M. Scott

AU - McKinney, Leslie

AU - Kollum, Marc

AU - Cottin, Yves

AU - Chan, Rosanna C.

AU - Barcellos-Hoff, Mary Helen

AU - Waksman, Ron

PY - 1999/10

Y1 - 1999/10

N2 - Restenosis is a common complication of percutaneous transluminal coronary angioplasty. Recent studies have demonstrated a striking reduction in the neointimal hyperplasia characteristic of restenosis following intracoronary radiation (IR), but the mechanisms by which radiation reduces neointima formation following balloon overstretch injury are not elucidated fully. In addition to direct antimitotic effects mediated via oxygen free radicals, ionizing radiation can induce the expression of numerous genes and thereby mediate indirect effects. Additionally, IR prevents restenosis at the cost of decreased healing and increased thrombosis, and we suggest that these adverse reactions can be modulated by adjunct pharmacology or gene-based strategies. This review discusses several genes and proteins modulated by radiation in the context of arterial injury, and their possible therapeutic relevance.

AB - Restenosis is a common complication of percutaneous transluminal coronary angioplasty. Recent studies have demonstrated a striking reduction in the neointimal hyperplasia characteristic of restenosis following intracoronary radiation (IR), but the mechanisms by which radiation reduces neointima formation following balloon overstretch injury are not elucidated fully. In addition to direct antimitotic effects mediated via oxygen free radicals, ionizing radiation can induce the expression of numerous genes and thereby mediate indirect effects. Additionally, IR prevents restenosis at the cost of decreased healing and increased thrombosis, and we suggest that these adverse reactions can be modulated by adjunct pharmacology or gene-based strategies. This review discusses several genes and proteins modulated by radiation in the context of arterial injury, and their possible therapeutic relevance.

KW - Latency-associated peptide (LAP)

KW - Nitric oxide (NO)

KW - Nitric oxide synthase

KW - Telomerase

KW - Terminal deoxynucleotidyl transferase (TUNEL)

KW - Thrombosis

KW - Transforming growth factor-β1 (TGF-β1)

UR - https://www.scopus.com/pages/publications/0033207018

U2 - 10.1016/S1522-1865(00)00026-3

DO - 10.1016/S1522-1865(00)00026-3

M3 - Article

C2 - 10828563

AN - SCOPUS:0033207018

SN - 1522-1865

VL - 1

SP - 336

EP - 343

JO - Cardiovascular Radiation Medicine

JF - Cardiovascular Radiation Medicine

IS - 4

ER -

Modulation of protein expression and activity by radiation: Relevance to intracoronary radiation for the prevention of restenosis

Abstract

Keywords

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