Molecular Analysis of Clinically Defined Subsets of High-Grade Serous Ovarian Cancer

Sanghoon Lee; Li Zhao; Christine Rojas; Nicholas W. Bateman; Hui Yao; Olivia D. Lara; Joseph Celestino; Margaret B. Morgan; Tri V. Nguyen; Kelly A. Conrads; Kelly M. Rangel; Robert L. Dood; Richard A. Hajek; Gloria L. Fawcett; Randy A. Chu; Katlin Wilson; Jeremy L. Loffredo; Coralie Viollet; Amir A. Jazaeri; Clifton L. Dalgard; Xizeng Mao; Xingzhi Song; Ming Zhou; Brian L. Hood; Nirad Banskota; Matthew D. Wilkerson; Jerez Te; Anthony R. Soltis; Kristin Roman; Andrew Dunn; David Cordover; Agda Karina Eterovic; Jinsong Liu; Jared K. Burks; Keith A. Baggerly; Nicole D. Fleming; Karen H. Lu; Shannon N. Westin; Robert L. Coleman; Gordon B. Mills; Yovanni Casablanca; Jianhua Zhang; Thomas P. Conrads; George L. Maxwell; P. Andrew Futreal; Anil K. Sood

doi:10.1016/j.celrep.2020.03.066

Molecular Analysis of Clinically Defined Subsets of High-Grade Serous Ovarian Cancer

Sanghoon Lee, Li Zhao, Christine Rojas, Nicholas W. Bateman, Hui Yao, Olivia D. Lara, Joseph Celestino, Margaret B. Morgan, Tri V. Nguyen, Kelly A. Conrads, Kelly M. Rangel, Robert L. Dood, Richard A. Hajek, Gloria L. Fawcett, Randy A. Chu, Katlin Wilson, Jeremy L. Loffredo, Coralie Viollet, Amir A. Jazaeri, Clifton L. DalgardXizeng Mao, Xingzhi Song, Ming Zhou, Brian L. Hood, Nirad Banskota, Matthew D. Wilkerson, Jerez Te, Anthony R. Soltis, Kristin Roman, Andrew Dunn, David Cordover, Agda Karina Eterovic, Jinsong Liu, Jared K. Burks, Keith A. Baggerly, Nicole D. Fleming, Karen H. Lu, Shannon N. Westin, Robert L. Coleman, Gordon B. Mills, Yovanni Casablanca, Jianhua Zhang, Thomas P. Conrads, George L. Maxwell, P. Andrew Futreal, Anil K. Sood^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

85 Scopus citations

Abstract

High-grade serous ovarian cancer (HGSC) patients with no gross residual disease (R0) after primary surgery have the greatest improvement in clinical outcomes. A deep understanding of molecular and cellular heterogeneity of HGSC is lacking. Findings by Lee et al. highlight major molecular and cellular differences between clinically defined subgroups of HGSC.

Original language	English
Article number	107502
Journal	Cell Reports
Volume	31
Issue number	2
DOIs	https://doi.org/10.1016/j.celrep.2020.03.066
State	Published - 14 Apr 2020
Externally published	Yes

Keywords

R0 resection
copy number
genomics
immune monitoring
multi-omics
mutation
neoadjuvant chemotherapy
ovarian cancer
proteome
transcriptome

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10.1016/j.celrep.2020.03.066

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Lee, S., Zhao, L., Rojas, C., Bateman, N. W., Yao, H., Lara, O. D., Celestino, J., Morgan, M. B., Nguyen, T. V., Conrads, K. A., Rangel, K. M., Dood, R. L., Hajek, R. A., Fawcett, G. L., Chu, R. A., Wilson, K., Loffredo, J. L., Viollet, C., Jazaeri, A. A., ... Sood, A. K. (2020). Molecular Analysis of Clinically Defined Subsets of High-Grade Serous Ovarian Cancer. Cell Reports, 31(2), Article 107502. https://doi.org/10.1016/j.celrep.2020.03.066

@article{4b521430ab0346429ec8fbdb8a70ae68,

title = "Molecular Analysis of Clinically Defined Subsets of High-Grade Serous Ovarian Cancer",

abstract = "High-grade serous ovarian cancer (HGSC) patients with no gross residual disease (R0) after primary surgery have the greatest improvement in clinical outcomes. A deep understanding of molecular and cellular heterogeneity of HGSC is lacking. Findings by Lee et al. highlight major molecular and cellular differences between clinically defined subgroups of HGSC.",

keywords = "R0 resection, copy number, genomics, immune monitoring, multi-omics, mutation, neoadjuvant chemotherapy, ovarian cancer, proteome, transcriptome",

author = "Sanghoon Lee and Li Zhao and Christine Rojas and Bateman, {Nicholas W.} and Hui Yao and Lara, {Olivia D.} and Joseph Celestino and Morgan, {Margaret B.} and Nguyen, {Tri V.} and Conrads, {Kelly A.} and Rangel, {Kelly M.} and Dood, {Robert L.} and Hajek, {Richard A.} and Fawcett, {Gloria L.} and Chu, {Randy A.} and Katlin Wilson and Loffredo, {Jeremy L.} and Coralie Viollet and Jazaeri, {Amir A.} and Dalgard, {Clifton L.} and Xizeng Mao and Xingzhi Song and Ming Zhou and Hood, {Brian L.} and Nirad Banskota and Wilkerson, {Matthew D.} and Jerez Te and Soltis, {Anthony R.} and Kristin Roman and Andrew Dunn and David Cordover and Eterovic, {Agda Karina} and Jinsong Liu and Burks, {Jared K.} and Baggerly, {Keith A.} and Fleming, {Nicole D.} and Lu, {Karen H.} and Westin, {Shannon N.} and Coleman, {Robert L.} and Mills, {Gordon B.} and Yovanni Casablanca and Jianhua Zhang and Conrads, {Thomas P.} and Maxwell, {George L.} and Futreal, {P. Andrew} and Sood, {Anil K.}",

note = "Publisher Copyright: {\textcopyright} 2020 The Author(s)",

year = "2020",

month = apr,

day = "14",

doi = "10.1016/j.celrep.2020.03.066",

language = "English",

volume = "31",

journal = "Cell Reports",

issn = "2211-1247",

number = "2",

}

Lee, S, Zhao, L, Rojas, C, Bateman, NW, Yao, H, Lara, OD, Celestino, J, Morgan, MB, Nguyen, TV, Conrads, KA, Rangel, KM, Dood, RL, Hajek, RA, Fawcett, GL, Chu, RA, Wilson, K, Loffredo, JL, Viollet, C, Jazaeri, AA, Dalgard, CL, Mao, X, Song, X, Zhou, M, Hood, BL, Banskota, N, Wilkerson, MD, Te, J, Soltis, AR, Roman, K, Dunn, A, Cordover, D, Eterovic, AK, Liu, J, Burks, JK, Baggerly, KA, Fleming, ND, Lu, KH, Westin, SN, Coleman, RL, Mills, GB, Casablanca, Y, Zhang, J, Conrads, TP, Maxwell, GL, Futreal, PA & Sood, AK 2020, 'Molecular Analysis of Clinically Defined Subsets of High-Grade Serous Ovarian Cancer', Cell Reports, vol. 31, no. 2, 107502. https://doi.org/10.1016/j.celrep.2020.03.066

TY - JOUR

T1 - Molecular Analysis of Clinically Defined Subsets of High-Grade Serous Ovarian Cancer

AU - Lee, Sanghoon

AU - Zhao, Li

AU - Rojas, Christine

AU - Bateman, Nicholas W.

AU - Yao, Hui

AU - Lara, Olivia D.

AU - Celestino, Joseph

AU - Morgan, Margaret B.

AU - Nguyen, Tri V.

AU - Conrads, Kelly A.

AU - Rangel, Kelly M.

AU - Dood, Robert L.

AU - Hajek, Richard A.

AU - Fawcett, Gloria L.

AU - Chu, Randy A.

AU - Wilson, Katlin

AU - Loffredo, Jeremy L.

AU - Viollet, Coralie

AU - Jazaeri, Amir A.

AU - Dalgard, Clifton L.

AU - Mao, Xizeng

AU - Song, Xingzhi

AU - Zhou, Ming

AU - Hood, Brian L.

AU - Banskota, Nirad

AU - Wilkerson, Matthew D.

AU - Te, Jerez

AU - Soltis, Anthony R.

AU - Roman, Kristin

AU - Dunn, Andrew

AU - Cordover, David

AU - Eterovic, Agda Karina

AU - Liu, Jinsong

AU - Burks, Jared K.

AU - Baggerly, Keith A.

AU - Fleming, Nicole D.

AU - Lu, Karen H.

AU - Westin, Shannon N.

AU - Coleman, Robert L.

AU - Mills, Gordon B.

AU - Casablanca, Yovanni

AU - Zhang, Jianhua

AU - Conrads, Thomas P.

AU - Maxwell, George L.

AU - Futreal, P. Andrew

AU - Sood, Anil K.

PY - 2020/4/14

Y1 - 2020/4/14

N2 - High-grade serous ovarian cancer (HGSC) patients with no gross residual disease (R0) after primary surgery have the greatest improvement in clinical outcomes. A deep understanding of molecular and cellular heterogeneity of HGSC is lacking. Findings by Lee et al. highlight major molecular and cellular differences between clinically defined subgroups of HGSC.

AB - High-grade serous ovarian cancer (HGSC) patients with no gross residual disease (R0) after primary surgery have the greatest improvement in clinical outcomes. A deep understanding of molecular and cellular heterogeneity of HGSC is lacking. Findings by Lee et al. highlight major molecular and cellular differences between clinically defined subgroups of HGSC.

KW - R0 resection

KW - copy number

KW - genomics

KW - immune monitoring

KW - multi-omics

KW - mutation

KW - neoadjuvant chemotherapy

KW - ovarian cancer

KW - proteome

KW - transcriptome

UR - http://www.scopus.com/inward/record.url?scp=85083004505&partnerID=8YFLogxK

U2 - 10.1016/j.celrep.2020.03.066

DO - 10.1016/j.celrep.2020.03.066

M3 - Article

C2 - 32294438

AN - SCOPUS:85083004505

SN - 2211-1247

VL - 31

JO - Cell Reports

JF - Cell Reports

IS - 2

M1 - 107502

ER -

Molecular Analysis of Clinically Defined Subsets of High-Grade Serous Ovarian Cancer

Abstract

Keywords

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