Monoclonal gammopathy-associated pure red cell aplasia

Neha Korde; Yong Zhang; Kelsey Loeliger; Andrea Poon; Olga Simakova; Adriana Zingone; Rene Costello; Richard Childs; Pierre Noel; Samuel Silver; Mary Kwok; Clifton Mo; Neal Young; Ola Landgren; Elaine Sloand; Irina Maric

doi:10.1111/bjh.14012

Monoclonal gammopathy-associated pure red cell aplasia

Neha Korde^*, Yong Zhang, Kelsey Loeliger, Andrea Poon, Olga Simakova, Adriana Zingone, Rene Costello, Richard Childs, Pierre Noel, Samuel Silver, Mary Kwok, Clifton Mo, Neal Young, Ola Landgren, Elaine Sloand, Irina Maric

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Pure red cell aplasia (PRCA) is a rare disorder characterized by inhibition of erythroid precursors in the bone marrow and normochromic, normocytic anaemia with reticulocytopenia. Among 51 PRCA patients, we identified 12 (24%) patients having monoclonal gammopathy, monoclonal gammopathy of undetermined significance or smouldering multiple myeloma, with presence of monoclonal protein or abnormal serum free light chains and atypical bone marrow features of clonal plasmacytosis, hypercellularity and fibrosis. Thus far, three patients treated with anti-myeloma based therapeutics have responded with reticulocyte recovery and clinical transfusion independence, suggesting plasma cells play a key role in the pathogenesis of this specific monoclonal gammopathy-associated PRCA.

Original language	English
Pages (from-to)	876-883
Number of pages	8
Journal	British Journal of Haematology
Volume	173
Issue number	6
DOIs	https://doi.org/10.1111/bjh.14012
State	Published - 1 Jun 2016
Externally published	Yes

Keywords

anaemia
monoclonal gammopathy of undetermined significance
myeloma
plasmacytosis
pure red cell aplasia

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10.1111/bjh.14012

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title = "Monoclonal gammopathy-associated pure red cell aplasia",

abstract = "Pure red cell aplasia (PRCA) is a rare disorder characterized by inhibition of erythroid precursors in the bone marrow and normochromic, normocytic anaemia with reticulocytopenia. Among 51 PRCA patients, we identified 12 (24%) patients having monoclonal gammopathy, monoclonal gammopathy of undetermined significance or smouldering multiple myeloma, with presence of monoclonal protein or abnormal serum free light chains and atypical bone marrow features of clonal plasmacytosis, hypercellularity and fibrosis. Thus far, three patients treated with anti-myeloma based therapeutics have responded with reticulocyte recovery and clinical transfusion independence, suggesting plasma cells play a key role in the pathogenesis of this specific monoclonal gammopathy-associated PRCA.",

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author = "Neha Korde and Yong Zhang and Kelsey Loeliger and Andrea Poon and Olga Simakova and Adriana Zingone and Rene Costello and Richard Childs and Pierre Noel and Samuel Silver and Mary Kwok and Clifton Mo and Neal Young and Ola Landgren and Elaine Sloand and Irina Maric",

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doi = "10.1111/bjh.14012",

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T1 - Monoclonal gammopathy-associated pure red cell aplasia

AU - Korde, Neha

AU - Zhang, Yong

AU - Loeliger, Kelsey

AU - Poon, Andrea

AU - Simakova, Olga

AU - Zingone, Adriana

AU - Costello, Rene

AU - Childs, Richard

AU - Noel, Pierre

AU - Silver, Samuel

AU - Kwok, Mary

AU - Mo, Clifton

AU - Young, Neal

AU - Landgren, Ola

AU - Sloand, Elaine

AU - Maric, Irina

N1 - Publisher Copyright: Published 2016. This article is a U.S. Government work and is in the public domain in the USA.

PY - 2016/6/1

Y1 - 2016/6/1

N2 - Pure red cell aplasia (PRCA) is a rare disorder characterized by inhibition of erythroid precursors in the bone marrow and normochromic, normocytic anaemia with reticulocytopenia. Among 51 PRCA patients, we identified 12 (24%) patients having monoclonal gammopathy, monoclonal gammopathy of undetermined significance or smouldering multiple myeloma, with presence of monoclonal protein or abnormal serum free light chains and atypical bone marrow features of clonal plasmacytosis, hypercellularity and fibrosis. Thus far, three patients treated with anti-myeloma based therapeutics have responded with reticulocyte recovery and clinical transfusion independence, suggesting plasma cells play a key role in the pathogenesis of this specific monoclonal gammopathy-associated PRCA.

AB - Pure red cell aplasia (PRCA) is a rare disorder characterized by inhibition of erythroid precursors in the bone marrow and normochromic, normocytic anaemia with reticulocytopenia. Among 51 PRCA patients, we identified 12 (24%) patients having monoclonal gammopathy, monoclonal gammopathy of undetermined significance or smouldering multiple myeloma, with presence of monoclonal protein or abnormal serum free light chains and atypical bone marrow features of clonal plasmacytosis, hypercellularity and fibrosis. Thus far, three patients treated with anti-myeloma based therapeutics have responded with reticulocyte recovery and clinical transfusion independence, suggesting plasma cells play a key role in the pathogenesis of this specific monoclonal gammopathy-associated PRCA.

KW - anaemia

KW - monoclonal gammopathy of undetermined significance

KW - myeloma

KW - plasmacytosis

KW - pure red cell aplasia

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VL - 173

SP - 876

EP - 883

JO - British Journal of Haematology

JF - British Journal of Haematology

IS - 6

ER -

Monoclonal gammopathy-associated pure red cell aplasia

Abstract

Keywords

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