More than an accessory: Implications of type III transforming growth factor-β receptor loss in prostate cancer

Seun Ajiboye; Tristan M. Sissung; Nima Sharifi; William D. Figg

doi:10.1111/j.1464-410X.2009.08999.x

More than an accessory: Implications of type III transforming growth factor-β receptor loss in prostate cancer

Seun Ajiboye, Tristan M. Sissung, Nima Sharifi, William D. Figg

Research output: Contribution to journal › Short survey › peer-review

16 Scopus citations

Abstract

The type III transforming growth factor-β receptor (TGFβR3, betaglycan), a tumour suppressor, is the most frequently lost TGFβ pathway component. This event appears to be very important in the transition of the TGFβ pathway from having tumour-suppressor activity in early prostate tumour development, to having tumour-promoting activity in metastatic disease. Moreover, loss of the TGFβR3 can also affect the cellular response towards testosterone, inhibin/activin, and dysregulate growth-factor pathways that mediate growth and angiogenesis. In this review we discuss how TGFβR3 normally functions as an accessory protein in the TGFβ pathway, how its loss is related to tumour progression, and the treatment implications of TGFβR3 loss in individuals with prostate cancer.

Original language	English
Pages (from-to)	913-916
Number of pages	4
Journal	BJU International
Volume	105
Issue number	7
DOIs	https://doi.org/10.1111/j.1464-410X.2009.08999.x
State	Published - Apr 2010
Externally published	Yes

Keywords

Betaglycan
Prostate cancer
TGFβ III receptor
Testosterone

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10.1111/j.1464-410X.2009.08999.x

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abstract = "The type III transforming growth factor-β receptor (TGFβR3, betaglycan), a tumour suppressor, is the most frequently lost TGFβ pathway component. This event appears to be very important in the transition of the TGFβ pathway from having tumour-suppressor activity in early prostate tumour development, to having tumour-promoting activity in metastatic disease. Moreover, loss of the TGFβR3 can also affect the cellular response towards testosterone, inhibin/activin, and dysregulate growth-factor pathways that mediate growth and angiogenesis. In this review we discuss how TGFβR3 normally functions as an accessory protein in the TGFβ pathway, how its loss is related to tumour progression, and the treatment implications of TGFβR3 loss in individuals with prostate cancer.",

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AU - Sharifi, Nima

AU - Figg, William D.

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More than an accessory: Implications of type III transforming growth factor-β receptor loss in prostate cancer

Abstract

Keywords

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