Multidimensional machine learning models predicting outcomes after trauma

Dimitrios Moris*, Ricardo Henao, Hannah Hensman, Linda Stempora, Scott Chasse, Seth Schobel, Christopher J. Dente, Allan D. Kirk, Eric Elster

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Background: An emerging body of literature supports the role of individualized prognostic tools to guide the management of patients after trauma. The aim of this study was to develop advanced modeling tools from multidimensional data sources, including immunological analytes and clinical and administrative data, to predict outcomes in trauma patients. Methods: This was a prospective study of trauma patients at Level 1 centers from 2015 to 2019. Clinical, flow cytometry, and serum cytokine data were collected within 48 hours of admission. Sparse logistic regression models were developed, jointly selecting predictors and estimating the risk of ventilator-associated pneumonia, acute kidney injury, complicated disposition (death, rehabilitation, or nursing facility), and return to the operating room. Model parameters (regularization controlling model sparsity) and performance estimation were obtained via nested leave-one-out cross-validation. Results: A total of 179 patients were included. The incidences of ventilator-associated pneumonia, acute kidney injury, complicated disposition, and return to the operating room were 17.7%, 28.8%, 22.5%, and 12.3%, respectively. Regarding extensive resource use, 30.7% of patients had prolonged intensive care unit stay, 73.2% had prolonged length of stay, and 23.5% had need for prolonged ventilatory support. The models were developed and cross-validated for ventilator-associated pneumonia, acute kidney injury, complicated dispositions, and return to the operating room, yielding predictive areas under the curve from 0.70 to 0.91. Each model derived its optimal predictive value by combining clinical, administrative, and immunological analyte data. Conclusion: Clinical, immunological, and administrative data can be combined to predict post-traumatic outcomes and resource use. Multidimensional machine learning modeling can identify trauma patients with complicated clinical trajectories and high resource needs.

Original languageEnglish
Pages (from-to)1851-1859
Number of pages9
Issue number6
StatePublished - Dec 2022
Externally publishedYes


  • Acute Kidney Injury/diagnosis
  • Humans
  • Logistic Models
  • Machine Learning
  • Pneumonia, Ventilator-Associated/diagnosis
  • Prospective Studies
  • Retrospective Studies


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