Multisystem Inflammatory Syndrome in Children in February 2020 and Implications of Genomic Sequencing for SARS-CoV-2

Emily Parsons; Matthew Timlin; Clarise Starr; Anthony Fries; Ronald Wells; Matthew Studer; Rebecca Sainato

doi:10.1093/jpids/piaa167

Multisystem Inflammatory Syndrome in Children in February 2020 and Implications of Genomic Sequencing for SARS-CoV-2

Emily Parsons, Matthew Timlin, Clarise Starr, Anthony Fries, Ronald Wells, Matthew Studer, Rebecca Sainato^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Multisystem inflammatory syndrome in children (MIS-C) is a newly recognized disease process that can complicate severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We present what we believe to be the earliest case of MIS-C, occurring in February 2020. Our patient's SARS-CoV-2 infection was caused by an emerging lineage with the D614G variant in the spike protein. This lineage would subsequently become the predominant cause of SARS-CoV-2 outbreaks in Europe and the United States where MIS-C was first described.

Original language	English
Pages (from-to)	695-697
Number of pages	3
Journal	Journal of the Pediatric Infectious Diseases Society
Volume	10
Issue number	5
DOIs	https://doi.org/10.1093/jpids/piaa167
State	Published - 1 May 2021

Keywords

COVID-19
D614G
MIS-C
pseudotumor cerebri syndrome
SARS-CoV-2
viral lineage

Access to Document

10.1093/jpids/piaa167

Cite this

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title = "Multisystem Inflammatory Syndrome in Children in February 2020 and Implications of Genomic Sequencing for SARS-CoV-2",

abstract = "Multisystem inflammatory syndrome in children (MIS-C) is a newly recognized disease process that can complicate severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We present what we believe to be the earliest case of MIS-C, occurring in February 2020. Our patient's SARS-CoV-2 infection was caused by an emerging lineage with the D614G variant in the spike protein. This lineage would subsequently become the predominant cause of SARS-CoV-2 outbreaks in Europe and the United States where MIS-C was first described.",

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AU - Wells, Ronald

AU - Studer, Matthew

AU - Sainato, Rebecca

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AB - Multisystem inflammatory syndrome in children (MIS-C) is a newly recognized disease process that can complicate severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We present what we believe to be the earliest case of MIS-C, occurring in February 2020. Our patient's SARS-CoV-2 infection was caused by an emerging lineage with the D614G variant in the spike protein. This lineage would subsequently become the predominant cause of SARS-CoV-2 outbreaks in Europe and the United States where MIS-C was first described.

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