Murine immunization by cesium-137 irradiation attenuated Schistosoma mansoni cercariae

M. Stek, P. Minard, D. F. Cruess

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Cesium-137, becoming a more readily available ionizing gamma radiation source for laboratory use, was shown to effectively attenuate Schistosoma mansoni cercariae for vaccine production. In parallel comparison studies with the murine model, cesium-137 attenuated cercariae consistently afforded better (P > 0.05) protection than did the cobalt-60 prepared vaccine. Dose-response data indicated that the optimal total irradiation with cesium-137 was between 45 and 50 Krad.

Original languageEnglish
Pages (from-to)398-402
Number of pages5
JournalJournal of Parasitology
Volume70
Issue number3
DOIs
StatePublished - 1984
Externally publishedYes

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