Myocardial repair with ECM scaffolds

Stephen Badylak*

*Corresponding author for this work

Research output: Contribution to journalConference articlepeer-review


Surgically-created, full-thickness defects in the right ventricle, measuring approximately 1.5 cm in diameter, were repaired with a sheet of either UBS or SIS measuring approximately 80 mm in thickness. Animals were sacrificed at periods of time ranging from 6 weeks to 5 months post surgery. There was replacement of the scaffolds by viable and contractile myocardium intermixed with bands of collagenous connective tissue. The thickness of the newly formed myocardium approximated that of the adjacent native myocardium by 3 months. The neo-endocardium was morphologically normal and covered by normal endothelial cells. In vitro contractility tests showed that the remodeled tissue could generate contractile forces up to 70% of that produced by native myocardium.

Original languageEnglish
Pages (from-to)S-58
JournalAnnals of Biomedical Engineering
Issue numberSUPPL. 1
StatePublished - 2000
Externally publishedYes
Event2000 Annual Fall Meeting of the Biomedical Engineering Society - Washington, WA, USA
Duration: 12 Oct 200014 Oct 2000


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