Myogenic tissue nanotransfection improves muscle torque recovery following volumetric muscle loss

Andrew Clark; Subhadip Ghatak; Poornachander Reddy Guda; Mohamed S. El Masry; Yi Xuan; Amy Y. Sato; Teresita Bellido; Chandan K. Sen

doi:10.1038/s41536-022-00259-y

Myogenic tissue nanotransfection improves muscle torque recovery following volumetric muscle loss

Andrew Clark, Subhadip Ghatak, Poornachander Reddy Guda, Mohamed S. El Masry, Yi Xuan, Amy Y. Sato, Teresita Bellido, Chandan K. Sen^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

This work rests on our non-viral tissue nanotransfection (TNT) platform to deliver MyoD (TNT_MyoD) to injured tissue in vivo. TNT_MyoD was performed on skin and successfully induced expression of myogenic factors. TNT_MyoD was then used as a therapy 7 days following volumetric muscle loss (VML) of rat tibialis anterior and rescued muscle function. TNT_MyoD is promising as VML intervention.

Original language	English
Article number	63
Journal	npj Regenerative Medicine
Volume	7
Issue number	1
DOIs	https://doi.org/10.1038/s41536-022-00259-y
State	Published - Dec 2022
Externally published	Yes

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title = "Myogenic tissue nanotransfection improves muscle torque recovery following volumetric muscle loss",

abstract = "This work rests on our non-viral tissue nanotransfection (TNT) platform to deliver MyoD (TNTMyoD) to injured tissue in vivo. TNTMyoD was performed on skin and successfully induced expression of myogenic factors. TNTMyoD was then used as a therapy 7 days following volumetric muscle loss (VML) of rat tibialis anterior and rescued muscle function. TNTMyoD is promising as VML intervention.",

author = "Andrew Clark and Subhadip Ghatak and Guda, {Poornachander Reddy} and {El Masry}, {Mohamed S.} and Yi Xuan and Sato, {Amy Y.} and Teresita Bellido and Sen, {Chandan K.}",

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AU - Ghatak, Subhadip

AU - Guda, Poornachander Reddy

AU - El Masry, Mohamed S.

AU - Xuan, Yi

AU - Sato, Amy Y.

AU - Bellido, Teresita

AU - Sen, Chandan K.

PY - 2022/12

Y1 - 2022/12

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AB - This work rests on our non-viral tissue nanotransfection (TNT) platform to deliver MyoD (TNTMyoD) to injured tissue in vivo. TNTMyoD was performed on skin and successfully induced expression of myogenic factors. TNTMyoD was then used as a therapy 7 days following volumetric muscle loss (VML) of rat tibialis anterior and rescued muscle function. TNTMyoD is promising as VML intervention.

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Myogenic tissue nanotransfection improves muscle torque recovery following volumetric muscle loss

Abstract

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