N-acetylaspartate (NAA) and N-acetylaspartylglutamate (NAAG) promote growth and inhibit differentiation of glioma stem-like cells

Patrick M. Long; John R. Moffett; Aryan M.A. Namboodiri; Mariano S. Viapiano; Sean E. Lawler; Diane M. Jaworski

doi:10.1074/jbc.M113.487553

N-acetylaspartate (NAA) and N-acetylaspartylglutamate (NAAG) promote growth and inhibit differentiation of glioma stem-like cells

Patrick M. Long
, John R. Moffett
, Aryan M.A. Namboodiri
, Mariano S. Viapiano
, Sean E. Lawler
, Diane M. Jaworski^*

^*Corresponding author for this work

Anatomy, Physiology, and Genetics

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

Background: N-acetylaspartate (NAA), the primary source of brain acetate, and aspartoacylase (ASPA), the enzyme that catabolizes NAA, are decreased in glioma, thereby decreasing acetate bioavailability. Results: Treatment with NAA and NAAG promotes growth and inhibits differentiation of glioma stem-like cells (GSCs). Conclusion: This study links acetate bioavailability and GSC malignancy. Significance: Because NAA/NAAG-mediated acetate supplementation promoted GSC growth, an alternative acetate therapeutic is required.

Original language	English
Pages (from-to)	26188-26200
Number of pages	13
Journal	Journal of Biological Chemistry
Volume	288
Issue number	36
DOIs	https://doi.org/10.1074/jbc.M113.487553
State	Published - 6 Sep 2013

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@article{c1da54a2318c4cc4875552763a547dfc,

title = "N-acetylaspartate (NAA) and N-acetylaspartylglutamate (NAAG) promote growth and inhibit differentiation of glioma stem-like cells",

abstract = "Background: N-acetylaspartate (NAA), the primary source of brain acetate, and aspartoacylase (ASPA), the enzyme that catabolizes NAA, are decreased in glioma, thereby decreasing acetate bioavailability. Results: Treatment with NAA and NAAG promotes growth and inhibits differentiation of glioma stem-like cells (GSCs). Conclusion: This study links acetate bioavailability and GSC malignancy. Significance: Because NAA/NAAG-mediated acetate supplementation promoted GSC growth, an alternative acetate therapeutic is required.",

author = "Long, \{Patrick M.\} and Moffett, \{John R.\} and Namboodiri, \{Aryan M.A.\} and Viapiano, \{Mariano S.\} and Lawler, \{Sean E.\} and Jaworski, \{Diane M.\}",

year = "2013",

month = sep,

day = "6",

doi = "10.1074/jbc.M113.487553",

language = "English",

volume = "288",

pages = "26188--26200",

journal = "Journal of Biological Chemistry",

issn = "0021-9258",

publisher = "American Society for Biochemistry and Molecular Biology Inc.",

number = "36",

}

TY - JOUR

T1 - N-acetylaspartate (NAA) and N-acetylaspartylglutamate (NAAG) promote growth and inhibit differentiation of glioma stem-like cells

AU - Long, Patrick M.

AU - Moffett, John R.

AU - Namboodiri, Aryan M.A.

AU - Viapiano, Mariano S.

AU - Lawler, Sean E.

AU - Jaworski, Diane M.

PY - 2013/9/6

Y1 - 2013/9/6

N2 - Background: N-acetylaspartate (NAA), the primary source of brain acetate, and aspartoacylase (ASPA), the enzyme that catabolizes NAA, are decreased in glioma, thereby decreasing acetate bioavailability. Results: Treatment with NAA and NAAG promotes growth and inhibits differentiation of glioma stem-like cells (GSCs). Conclusion: This study links acetate bioavailability and GSC malignancy. Significance: Because NAA/NAAG-mediated acetate supplementation promoted GSC growth, an alternative acetate therapeutic is required.

AB - Background: N-acetylaspartate (NAA), the primary source of brain acetate, and aspartoacylase (ASPA), the enzyme that catabolizes NAA, are decreased in glioma, thereby decreasing acetate bioavailability. Results: Treatment with NAA and NAAG promotes growth and inhibits differentiation of glioma stem-like cells (GSCs). Conclusion: This study links acetate bioavailability and GSC malignancy. Significance: Because NAA/NAAG-mediated acetate supplementation promoted GSC growth, an alternative acetate therapeutic is required.

UR - https://www.scopus.com/pages/publications/84883676327

U2 - 10.1074/jbc.M113.487553

DO - 10.1074/jbc.M113.487553

M3 - Article

C2 - 23884408

AN - SCOPUS:84883676327

SN - 0021-9258

VL - 288

SP - 26188

EP - 26200

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 36

ER -

N-acetylaspartate (NAA) and N-acetylaspartylglutamate (NAAG) promote growth and inhibit differentiation of glioma stem-like cells

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