Nanoparticle technology: Addressing the fundamental roadblocks to protein biomarker discovery

Alessandra Luchini; Caterina Longo; Virginia Espina; Emanuel F. Petricoin; Lance A. Liotta

doi:10.1039/b822264a

Nanoparticle technology: Addressing the fundamental roadblocks to protein biomarker discovery

Alessandra Luchini, Caterina Longo, Virginia Espina, Emanuel F. Petricoin, Lance A. Liotta

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

The incorporation of affinity baits into N-isopropylacrylamide-hydrogel- based nanoparticles offers a novel technology that addresses the major analytical challenges of disease biomarker discovery. In solution in complex biologic fluids (e.g. blood or urine), core-shell bait-containing nanoparticles can perform three functions in one step: (a) sieve molecules according to size, (b) sequestrate and concentrate target analytes, and (c) protect analytes from degradation.

Original language	English
Pages (from-to)	5071-5077
Number of pages	7
Journal	Journal of Materials Chemistry
Volume	19
Issue number	29
DOIs	https://doi.org/10.1039/b822264a
State	Published - 7 Aug 2009
Externally published	Yes

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abstract = "The incorporation of affinity baits into N-isopropylacrylamide-hydrogel- based nanoparticles offers a novel technology that addresses the major analytical challenges of disease biomarker discovery. In solution in complex biologic fluids (e.g. blood or urine), core-shell bait-containing nanoparticles can perform three functions in one step: (a) sieve molecules according to size, (b) sequestrate and concentrate target analytes, and (c) protect analytes from degradation.",

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AU - Petricoin, Emanuel F.

AU - Liotta, Lance A.

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Nanoparticle technology: Addressing the fundamental roadblocks to protein biomarker discovery

Abstract

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