TY - JOUR
T1 - Nanoparticles
T2 - Potential biomarker harvesters
AU - Geho, David H.
AU - Jones, Clinton D.
AU - Petricoin, Emanuel F.
AU - Liotta, Lance A.
PY - 2006/2
Y1 - 2006/2
N2 - A previously untapped bank of information resides within the low molecular weight proteomic fraction of blood. Intensive efforts are underway to harness this information so that it can be used for early diagnosis of diseases such as cancer. The physicochemical malleability and high surface areas of nanoparticle surfaces make them ideal candidates for developing biomarker harvesting platforms. Given the variety of engineering strategies afforded through nanoparticle technologies, a significant goal is to tailor nanoparticle surfaces to selectively bind a subset of biomarkers, sequestering them for later study using high sensitivity proteomic tests. To date, applications of nanoparticles have largely focused on imaging systems and drug delivery vectors. As such, biomarker harvesting is an underutilized application of nanoparticle technology and is an area of nanotechnology research that will likely undergo substantial growth.
AB - A previously untapped bank of information resides within the low molecular weight proteomic fraction of blood. Intensive efforts are underway to harness this information so that it can be used for early diagnosis of diseases such as cancer. The physicochemical malleability and high surface areas of nanoparticle surfaces make them ideal candidates for developing biomarker harvesting platforms. Given the variety of engineering strategies afforded through nanoparticle technologies, a significant goal is to tailor nanoparticle surfaces to selectively bind a subset of biomarkers, sequestering them for later study using high sensitivity proteomic tests. To date, applications of nanoparticles have largely focused on imaging systems and drug delivery vectors. As such, biomarker harvesting is an underutilized application of nanoparticle technology and is an area of nanotechnology research that will likely undergo substantial growth.
UR - http://www.scopus.com/inward/record.url?scp=32044462230&partnerID=8YFLogxK
U2 - 10.1016/j.cbpa.2006.01.003
DO - 10.1016/j.cbpa.2006.01.003
M3 - Review article
C2 - 16413816
AN - SCOPUS:32044462230
SN - 1367-5931
VL - 10
SP - 56
EP - 61
JO - Current Opinion in Chemical Biology
JF - Current Opinion in Chemical Biology
IS - 1
ER -