National adherence to the ASGE-SAGES guidelines for managing suspected choledocholithiasis: An EAST multicenter study

EAST Retained Common Bile Duct Stones Study Group

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3 Scopus citations

Abstract

BACKGROUND: The American Society for Gastrointestinal Endoscopy and Society of American Gastrointestinal and Endoscopic Surgeons provide guidelines for managing suspected common bile duct (CBD) stones. We sought to evaluate adherence to the guidelines among patients with choledocholithiasis and/or acute biliary pancreatitis (ABP) and to evaluate the ability of these guidelines to predict choledocholithiasis. METHODS: We prospectively identified patients undergoing same-admission cholecystectomy for choledocholithiasis and/or ABP from 2016 to 2019 at 12 United States medical centers. Predictors of suspected CBD stones were very strong (CBD stone on ultrasound; bilirubin >4 mg/dL), strong (CBD > 6 mm; bilirubin ≥1.8 to ≤4 mg/dL), or moderate (abnormal liver function tests other than bilirubin; age >55 years; ABP). Patients were grouped by probability of CBD stones: high (any very strong or both strong predictors), low (no predictors), or intermediate (any other predictor combination). The management of each probability group was compared with the recommended management in the guidelines. RESULTS: The cohort was comprised of 844 patients. High-probability patients had 64.3% (n = 238/370) deviation from guidelines, intermediate-probability patients had 29% (n = 132/455) deviation, and low-probability patients had 78.9% (n = 15/19) deviation. Acute biliary pancreatitis increased the odds of deviation for the high- (odds ratio [OR], 1.71; 95% confidence interval [CI], 1.06–2.8; p = 0.03) and intermediate-probability groups (OR, 1.6; 95% CI, 1.07–2.42; p = 0.02). Age older than 55 years (OR, 2.19; 95% CI, 1.4–3.43; p < 0.001) also increased the odds of deviation for the intermediate group. A CBD greater than 6 mm predicted choledocholithiasis in the high (adjusted OR (aOR), 2.16; 95% CI, 1.17–3.97; p = 0.01) and intermediate group (aOR, 2.78; 95% CI, 1.59–4.86; p < 0.001). Any very strong predictor (aOR, 2.43; 95% CI, 1.76–3.37; p < 0.0001) and both strong predictors predicted choledocholithiasis (aOR, 2; 95% CI, 1.35–2.96; p < 0.001). CONCLUSION: Almost 45% of patients with suspected CBD stones were managed discordantly from the American Society for Gastrointestinal Endoscopy and Society of American Gastrointestinal and Endoscopic Surgeons guidelines. We believe these guidelines warrant revision to better reflect the ability of the clinical variables at predicting choledocholithiasis. LEVEL OF EVIDENCE: Therapeutic/Care Management; Level IV.

Original languageEnglish
Pages (from-to)305-312
Number of pages8
JournalJournal of Trauma and Acute Care Surgery
Volume92
Issue number2
DOIs
StatePublished - 1 Feb 2022
Externally publishedYes

Keywords

  • ASGE
  • Acute biliary pancreatitis
  • Choledocholithiasis
  • Guidelines
  • SAGES

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