Natural biomaterials for regenerative medicine applications

Denver M. Faulk*, Stephen F. Badylak

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

14 Scopus citations


This chapter reviews the use of naturally occurring biomaterials for tissue repair and regeneration and the effects of tissue source and processing methods for these materials upon the host response. The pros and cons of naturally biologic scaffolds are discussed. Methods for the preparation of biologic scaffolds are shown to have a critical effect upon functionality of the device. The mechanisms by which biologic scaffolds composed of extracellular matrix can alter the default wound healing response from the well-described pro-inflammatory and scarring events toward a more constructive remodeling response, i.e., the site appropriate formation of functional tissue, are discussed in detail.

Original languageEnglish
Title of host publicationRegenerative Medicine Applications in Organ Transplantation
PublisherElsevier Inc.
Number of pages12
ISBN (Print)9780123985231
StatePublished - 2014
Externally publishedYes


  • Acellular bioscaffold
  • Biologic scaffold
  • Biomaterial
  • Decellularization
  • Extracellularization


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