Nature of soft tissue calcification in uremia

S. R. Contiguglia; A. C. Alfrey; N. L. Miller; D. E. Runnells; R. Z. Le Geros

doi:10.1038/ki.1973.104

Nature of soft tissue calcification in uremia

S. R. Contiguglia, A. C. Alfrey, N. L. Miller, D. E. Runnells, R. Z. Le Geros

Research output: Contribution to journal › Article › peer-review

131 Scopus citations

Abstract

The chemical and crystalline composition of metastatic calcification was studied in 21 uremic patients. Nonvisceral calcification has a calcium/magnesium/phosphorus (Ca:Mg:P) molar ratio of 30/1/18 and an apatitic X ray diffraction pattern. The molar ratio of Ca/Mg/P in 33 tissue specimens (heart, lung and skeletal muscle) with calcification obtained from 19 uremic patients was 4.9/1/4.6, and X ray diffraction showed only an amorphous pattern. Following incineration at 500° C, the diffraction pattern of magnesium whitlockite (CaMg)₃(PO₄)₂ was found. This study demonstrates two distinct forms of calcium phosphate deposits in uremic patients. Nonvisceral and arterial calcification are hydroxyapatite. Calcification in heart, lung and skeletal muscle is an amorphous or microcrystalline compound composed of Ca/Mg/P in a constant molar ratio and is somewhat like whitlockite. The different tissue response incited by these two compounds is probably related to the larger crystal size found in nonvisceral calcification.

Original language	English
Pages (from-to)	229-235
Number of pages	7
Journal	Unknown Journal
Volume	4
Issue number	3
DOIs	https://doi.org/10.1038/ki.1973.104
State	Published - 1973
Externally published	Yes

Access to Document

10.1038/ki.1973.104

Cite this

@article{2edaf118ca684efdb80e648c6724693a,

title = "Nature of soft tissue calcification in uremia",

abstract = "The chemical and crystalline composition of metastatic calcification was studied in 21 uremic patients. Nonvisceral calcification has a calcium/magnesium/phosphorus (Ca:Mg:P) molar ratio of 30/1/18 and an apatitic X ray diffraction pattern. The molar ratio of Ca/Mg/P in 33 tissue specimens (heart, lung and skeletal muscle) with calcification obtained from 19 uremic patients was 4.9/1/4.6, and X ray diffraction showed only an amorphous pattern. Following incineration at 500° C, the diffraction pattern of magnesium whitlockite (CaMg)3(PO4)2 was found. This study demonstrates two distinct forms of calcium phosphate deposits in uremic patients. Nonvisceral and arterial calcification are hydroxyapatite. Calcification in heart, lung and skeletal muscle is an amorphous or microcrystalline compound composed of Ca/Mg/P in a constant molar ratio and is somewhat like whitlockite. The different tissue response incited by these two compounds is probably related to the larger crystal size found in nonvisceral calcification.",

author = "Contiguglia, {S. R.} and Alfrey, {A. C.} and Miller, {N. L.} and Runnells, {D. E.} and {Le Geros}, {R. Z.}",

note = "Funding Information: This study was supported in part by Veterans Administia- tion research grant 0233.02 and by U.S. Public Health Service grant RR-51 from the General Clinical Research program of the Division of Research Resources, National Institutes of Health. Ms. Dottie Goodman provided secre-tarial assistance.",

year = "1973",

doi = "10.1038/ki.1973.104",

language = "English",

volume = "4",

pages = "229--235",

journal = "Unknown Journal",

number = "3",

}

TY - JOUR

T1 - Nature of soft tissue calcification in uremia

AU - Contiguglia, S. R.

AU - Alfrey, A. C.

AU - Miller, N. L.

AU - Runnells, D. E.

AU - Le Geros, R. Z.

N1 - Funding Information: This study was supported in part by Veterans Administia- tion research grant 0233.02 and by U.S. Public Health Service grant RR-51 from the General Clinical Research program of the Division of Research Resources, National Institutes of Health. Ms. Dottie Goodman provided secre-tarial assistance.

PY - 1973

Y1 - 1973

N2 - The chemical and crystalline composition of metastatic calcification was studied in 21 uremic patients. Nonvisceral calcification has a calcium/magnesium/phosphorus (Ca:Mg:P) molar ratio of 30/1/18 and an apatitic X ray diffraction pattern. The molar ratio of Ca/Mg/P in 33 tissue specimens (heart, lung and skeletal muscle) with calcification obtained from 19 uremic patients was 4.9/1/4.6, and X ray diffraction showed only an amorphous pattern. Following incineration at 500° C, the diffraction pattern of magnesium whitlockite (CaMg)3(PO4)2 was found. This study demonstrates two distinct forms of calcium phosphate deposits in uremic patients. Nonvisceral and arterial calcification are hydroxyapatite. Calcification in heart, lung and skeletal muscle is an amorphous or microcrystalline compound composed of Ca/Mg/P in a constant molar ratio and is somewhat like whitlockite. The different tissue response incited by these two compounds is probably related to the larger crystal size found in nonvisceral calcification.

AB - The chemical and crystalline composition of metastatic calcification was studied in 21 uremic patients. Nonvisceral calcification has a calcium/magnesium/phosphorus (Ca:Mg:P) molar ratio of 30/1/18 and an apatitic X ray diffraction pattern. The molar ratio of Ca/Mg/P in 33 tissue specimens (heart, lung and skeletal muscle) with calcification obtained from 19 uremic patients was 4.9/1/4.6, and X ray diffraction showed only an amorphous pattern. Following incineration at 500° C, the diffraction pattern of magnesium whitlockite (CaMg)3(PO4)2 was found. This study demonstrates two distinct forms of calcium phosphate deposits in uremic patients. Nonvisceral and arterial calcification are hydroxyapatite. Calcification in heart, lung and skeletal muscle is an amorphous or microcrystalline compound composed of Ca/Mg/P in a constant molar ratio and is somewhat like whitlockite. The different tissue response incited by these two compounds is probably related to the larger crystal size found in nonvisceral calcification.

UR - http://www.scopus.com/inward/record.url?scp=0015907558&partnerID=8YFLogxK

U2 - 10.1038/ki.1973.104

DO - 10.1038/ki.1973.104

M3 - Article

C2 - 4750913

AN - SCOPUS:0015907558

VL - 4

SP - 229

EP - 235

JO - Unknown Journal

JF - Unknown Journal

IS - 3

ER -

Nature of soft tissue calcification in uremia

Abstract

Access to Document

Fingerprint

Cite this