Necrotizing enterocolitis

Ivan D. Frantz; Philippe L'Heureux; Rolf R. Engel; Carl E. Hunt

doi:10.1016/S0022-3476(75)80485-9

Necrotizing enterocolitis

Ivan D. Frantz
, Philippe L'Heureux
, Rolf R. Engel
, Carl E. Hunt^*

^*Corresponding author for this work

Pediatrics

Research output: Contribution to journal › Article › peer-review

144 Scopus citations

Abstract

The clinical course of 54 patients with necrotizing enterocolitis has been compared to a matched group of 98 control patients. On the day of life that NEC occurred, all 54 NEC patients and 63% of controls were receiving standard formula feedings, both at 80/cal/kg/day. Stool cultures at that time revealed a significantly increased frequency of Klebsiella in NEC as compared to control patients. Our data suggest that the combined presence of certain intestinal bacteria and enteric feedings, perhaps requiring a background of mucosal ischemia, may be of etiologic significance in the development of NEC and its radiologic hallmark, pneumatosis intestinalis.

Original language	English
Pages (from-to)	259-263
Number of pages	5
Journal	The Journal of Pediatrics
Volume	86
Issue number	2
DOIs	https://doi.org/10.1016/S0022-3476(75)80485-9
State	Published - Feb 1975

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title = "Necrotizing enterocolitis",

abstract = "The clinical course of 54 patients with necrotizing enterocolitis has been compared to a matched group of 98 control patients. On the day of life that NEC occurred, all 54 NEC patients and 63\% of controls were receiving standard formula feedings, both at 80/cal/kg/day. Stool cultures at that time revealed a significantly increased frequency of Klebsiella in NEC as compared to control patients. Our data suggest that the combined presence of certain intestinal bacteria and enteric feedings, perhaps requiring a background of mucosal ischemia, may be of etiologic significance in the development of NEC and its radiologic hallmark, pneumatosis intestinalis.",

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AU - Frantz, Ivan D.

AU - L'Heureux, Philippe

AU - Engel, Rolf R.

AU - Hunt, Carl E.

PY - 1975/2

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N2 - The clinical course of 54 patients with necrotizing enterocolitis has been compared to a matched group of 98 control patients. On the day of life that NEC occurred, all 54 NEC patients and 63% of controls were receiving standard formula feedings, both at 80/cal/kg/day. Stool cultures at that time revealed a significantly increased frequency of Klebsiella in NEC as compared to control patients. Our data suggest that the combined presence of certain intestinal bacteria and enteric feedings, perhaps requiring a background of mucosal ischemia, may be of etiologic significance in the development of NEC and its radiologic hallmark, pneumatosis intestinalis.

AB - The clinical course of 54 patients with necrotizing enterocolitis has been compared to a matched group of 98 control patients. On the day of life that NEC occurred, all 54 NEC patients and 63% of controls were receiving standard formula feedings, both at 80/cal/kg/day. Stool cultures at that time revealed a significantly increased frequency of Klebsiella in NEC as compared to control patients. Our data suggest that the combined presence of certain intestinal bacteria and enteric feedings, perhaps requiring a background of mucosal ischemia, may be of etiologic significance in the development of NEC and its radiologic hallmark, pneumatosis intestinalis.

UR - https://www.scopus.com/pages/publications/0016437169

U2 - 10.1016/S0022-3476(75)80485-9

DO - 10.1016/S0022-3476(75)80485-9

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VL - 86

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EP - 263

JO - The Journal of Pediatrics

JF - The Journal of Pediatrics

IS - 2

ER -

Necrotizing enterocolitis

Abstract

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