Neglected No More: Emerging Cellular Therapies in Traumatic Injury

Lacy E. Lowry; Maryanne C. Herzig; Barbara A. Christy; Richard Schäfer; Shibani Pati; Andrew P. Cap; James A. Bynum

doi:10.1007/s12015-020-10086-7

Neglected No More: Emerging Cellular Therapies in Traumatic Injury

Lacy E. Lowry, Maryanne C. Herzig, Barbara A. Christy^*, Richard Schäfer, Shibani Pati, Andrew P. Cap, James A. Bynum

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

4 Scopus citations

Abstract

Traumatic injuries are a leading cause of death and disability in both military and civilian populations. Given the complexity and diversity of traumatic injuries, novel and individualized treatment strategies are required to optimize outcomes. Cellular therapies have potential benefit for the treatment of acute or chronic injuries, and various cell-based pharmaceuticals are currently being tested in preclinical studies or in clinical trials. Cellular therapeutics may have the ability to complement existing therapies, especially in restoring organ function lost due to tissue disruption, prolonged hypoxia or inflammatory damage. In this article we highlight the current status and discuss future directions of cellular therapies for the treatment of traumatic injury. Both published research and ongoing clinical trials are discussed here. Graphical abstract: [Figure not available: see fulltext.]

Original language	English
Pages (from-to)	1194-1214
Number of pages	21
Journal	Stem Cell Reviews and Reports
Volume	17
Issue number	4
DOIs	https://doi.org/10.1007/s12015-020-10086-7
State	Published - Aug 2021
Externally published	Yes

Keywords

Cell therapy
Trauma

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10.1007/s12015-020-10086-7

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title = "Neglected No More: Emerging Cellular Therapies in Traumatic Injury",

abstract = "Traumatic injuries are a leading cause of death and disability in both military and civilian populations. Given the complexity and diversity of traumatic injuries, novel and individualized treatment strategies are required to optimize outcomes. Cellular therapies have potential benefit for the treatment of acute or chronic injuries, and various cell-based pharmaceuticals are currently being tested in preclinical studies or in clinical trials. Cellular therapeutics may have the ability to complement existing therapies, especially in restoring organ function lost due to tissue disruption, prolonged hypoxia or inflammatory damage. In this article we highlight the current status and discuss future directions of cellular therapies for the treatment of traumatic injury. Both published research and ongoing clinical trials are discussed here. Graphical abstract: [Figure not available: see fulltext.]",

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T2 - Emerging Cellular Therapies in Traumatic Injury

AU - Lowry, Lacy E.

AU - Herzig, Maryanne C.

AU - Christy, Barbara A.

AU - Schäfer, Richard

AU - Pati, Shibani

AU - Cap, Andrew P.

AU - Bynum, James A.

PY - 2021/8

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N2 - Traumatic injuries are a leading cause of death and disability in both military and civilian populations. Given the complexity and diversity of traumatic injuries, novel and individualized treatment strategies are required to optimize outcomes. Cellular therapies have potential benefit for the treatment of acute or chronic injuries, and various cell-based pharmaceuticals are currently being tested in preclinical studies or in clinical trials. Cellular therapeutics may have the ability to complement existing therapies, especially in restoring organ function lost due to tissue disruption, prolonged hypoxia or inflammatory damage. In this article we highlight the current status and discuss future directions of cellular therapies for the treatment of traumatic injury. Both published research and ongoing clinical trials are discussed here. Graphical abstract: [Figure not available: see fulltext.]

AB - Traumatic injuries are a leading cause of death and disability in both military and civilian populations. Given the complexity and diversity of traumatic injuries, novel and individualized treatment strategies are required to optimize outcomes. Cellular therapies have potential benefit for the treatment of acute or chronic injuries, and various cell-based pharmaceuticals are currently being tested in preclinical studies or in clinical trials. Cellular therapeutics may have the ability to complement existing therapies, especially in restoring organ function lost due to tissue disruption, prolonged hypoxia or inflammatory damage. In this article we highlight the current status and discuss future directions of cellular therapies for the treatment of traumatic injury. Both published research and ongoing clinical trials are discussed here. Graphical abstract: [Figure not available: see fulltext.]

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Neglected No More: Emerging Cellular Therapies in Traumatic Injury

Abstract

Keywords

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