TY - JOUR
T1 - Neonatal outcomes with different betamethasone dosing regimens
T2 - A comparison
AU - Haas, David M.
AU - McCullough, William
AU - Olsen, Cara H.
AU - Shiau, Daniel T.
AU - Richard, John
AU - Fry, Emory A.
AU - McNamara, Michael F.
PY - 2005/12
Y1 - 2005/12
N2 - OBJECTIVE: To determine any differences in neonatal outcomes when dosing betamethasone every 12 hours vs. 24 hours for anticipated preterm delivery. STUDY DESIGN: A retrospective review of births at < 36 weeks' gestation from January 1, 1996, to July 1, 2000. Maternal and neonatal charts were reviewed. The deliveries were separated into 3 groups: those not receiving antenatal corticosteroids, those who received betamethasone 12 hours apart and those who received 24-hour dosing. Demographic, obstetric and neonatal variables were compared between the groups. RESULTS: There were 909 deliveries analyzed. With the 2 betamethasone groups, a significant difference was found for more maternal antibiotic use (90.4% s. 83.6%, p = 0.03), venous cord blood gas pH (7.31 vs. 7.32, p = 0.04) and neonatal surfactant use (39.8% vs. 25.5%, p = 0.001) in the 12-hour group as compared to the 24-hour group. For all other outcomes there was no difference. CONCLUSION: Outcomes using a 12-hour dosing schedule of betamethasone were similar to those using a 24-hour regimen in this retrospective review. Twelve-hour dosing could be considered an alternative way to deliver antenatal corticosteroids.
AB - OBJECTIVE: To determine any differences in neonatal outcomes when dosing betamethasone every 12 hours vs. 24 hours for anticipated preterm delivery. STUDY DESIGN: A retrospective review of births at < 36 weeks' gestation from January 1, 1996, to July 1, 2000. Maternal and neonatal charts were reviewed. The deliveries were separated into 3 groups: those not receiving antenatal corticosteroids, those who received betamethasone 12 hours apart and those who received 24-hour dosing. Demographic, obstetric and neonatal variables were compared between the groups. RESULTS: There were 909 deliveries analyzed. With the 2 betamethasone groups, a significant difference was found for more maternal antibiotic use (90.4% s. 83.6%, p = 0.03), venous cord blood gas pH (7.31 vs. 7.32, p = 0.04) and neonatal surfactant use (39.8% vs. 25.5%, p = 0.001) in the 12-hour group as compared to the 24-hour group. For all other outcomes there was no difference. CONCLUSION: Outcomes using a 12-hour dosing schedule of betamethasone were similar to those using a 24-hour regimen in this retrospective review. Twelve-hour dosing could be considered an alternative way to deliver antenatal corticosteroids.
KW - Betamethasone
KW - Neonate
KW - Pregnancy outcomes
UR - http://www.scopus.com/inward/record.url?scp=29744438184&partnerID=8YFLogxK
M3 - Review article
C2 - 16444891
AN - SCOPUS:29744438184
SN - 0024-7758
VL - 50
SP - 915
EP - 922
JO - Journal of Reproductive Medicine for the Obstetrician and Gynecologist
JF - Journal of Reproductive Medicine for the Obstetrician and Gynecologist
IS - 12
ER -