Network-targeted combination therapy: A new concept in cancer treatment

Robyn P. Araujo*, Connemara Doran, Lance A. Liotta, Emanuel F. Petricoin

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

24 Scopus citations

Abstract

Toxicity is a major concern for anti-neoplastic drugs, with much of the existing pharmacopoeia being characterized by a very narrow therapeutic index. 'Network-targeted' combination therapy is a promising new concept in cancer therapy, whereby therapeutic index might be improved by targeting multiple nodes in a cell's signaling network, rather than a single node. Here, we examine the potential of this novel approach, illustrating how therapeutic benefit could be achieved with smaller doses of the necessary agents.

Original languageEnglish
Pages (from-to)425-433
Number of pages9
JournalDrug Discovery Today: Therapeutic Strategies
Volume1
Issue number4
DOIs
StatePublished - Dec 2004

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