TY - JOUR
T1 - Network-targeted combination therapy
T2 - A new concept in cancer treatment
AU - Araujo, Robyn P.
AU - Doran, Connemara
AU - Liotta, Lance A.
AU - Petricoin, Emanuel F.
PY - 2004/12
Y1 - 2004/12
N2 - Toxicity is a major concern for anti-neoplastic drugs, with much of the existing pharmacopoeia being characterized by a very narrow therapeutic index. 'Network-targeted' combination therapy is a promising new concept in cancer therapy, whereby therapeutic index might be improved by targeting multiple nodes in a cell's signaling network, rather than a single node. Here, we examine the potential of this novel approach, illustrating how therapeutic benefit could be achieved with smaller doses of the necessary agents.
AB - Toxicity is a major concern for anti-neoplastic drugs, with much of the existing pharmacopoeia being characterized by a very narrow therapeutic index. 'Network-targeted' combination therapy is a promising new concept in cancer therapy, whereby therapeutic index might be improved by targeting multiple nodes in a cell's signaling network, rather than a single node. Here, we examine the potential of this novel approach, illustrating how therapeutic benefit could be achieved with smaller doses of the necessary agents.
UR - http://www.scopus.com/inward/record.url?scp=13344294297&partnerID=8YFLogxK
U2 - 10.1016/j.ddstr.2004.11.004
DO - 10.1016/j.ddstr.2004.11.004
M3 - Review article
AN - SCOPUS:13344294297
SN - 1740-6773
VL - 1
SP - 425
EP - 433
JO - Drug Discovery Today: Therapeutic Strategies
JF - Drug Discovery Today: Therapeutic Strategies
IS - 4
ER -