Neuromelanin-containing neurons of the substantia nigra accumulate iron and aluminum in Parkinson's disease: a LAMMA study

Paul F. Good; C. W. Olanow; Daniel P. Perl

doi:10.1016/0006-8993(92)91334-B

Neuromelanin-containing neurons of the substantia nigra accumulate iron and aluminum in Parkinson's disease: a LAMMA study

Paul F. Good
, C. W. Olanow
, Daniel P. Perl^*

^*Corresponding author for this work

Pathology

Research output: Contribution to journal › Article › peer-review

419 Scopus citations

Abstract

The Laser Microprobe Mass Analyzer (LAMMA) is a sensitive instrument for identifying and localizing trace elements in tissue samples. Using LAMMA, we have examined melanin-containing neurons of the substantia nigra in patients with Parkinson's disease (PD) and controls. We found that iron significantly accumulates within neuromelanin granules of patients with PD compared to controls. Increased aluminum was found in the neuromelanin granules of 2 of 3 PD cases but in no controls. The accumulation of iron and aluminum, which are known to promote oxidant stress, may account for the selective degeneration of neuromelanin-containing neurons in PD.

Original language	English
Pages (from-to)	343-346
Number of pages	4
Journal	Brain Research
Volume	593
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(92)91334-B
State	Published - 16 Oct 1992

Keywords

Aluminum
Iron
Laser Microprobe Mass Analyzer
Neuromelanin
Oxidant stress
Parkinson's disease

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10.1016/0006-8993(92)91334-B

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title = "Neuromelanin-containing neurons of the substantia nigra accumulate iron and aluminum in Parkinson's disease: a LAMMA study",

abstract = "The Laser Microprobe Mass Analyzer (LAMMA) is a sensitive instrument for identifying and localizing trace elements in tissue samples. Using LAMMA, we have examined melanin-containing neurons of the substantia nigra in patients with Parkinson's disease (PD) and controls. We found that iron significantly accumulates within neuromelanin granules of patients with PD compared to controls. Increased aluminum was found in the neuromelanin granules of 2 of 3 PD cases but in no controls. The accumulation of iron and aluminum, which are known to promote oxidant stress, may account for the selective degeneration of neuromelanin-containing neurons in PD.",

keywords = "Aluminum, Iron, Laser Microprobe Mass Analyzer, Neuromelanin, Oxidant stress, Parkinson's disease",

author = "Good, \{Paul F.\} and Olanow, \{C. W.\} and Perl, \{Daniel P.\}",

year = "1992",

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journal = "Brain Research",

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T1 - Neuromelanin-containing neurons of the substantia nigra accumulate iron and aluminum in Parkinson's disease

T2 - a LAMMA study

AU - Good, Paul F.

AU - Olanow, C. W.

AU - Perl, Daniel P.

PY - 1992/10/16

Y1 - 1992/10/16

N2 - The Laser Microprobe Mass Analyzer (LAMMA) is a sensitive instrument for identifying and localizing trace elements in tissue samples. Using LAMMA, we have examined melanin-containing neurons of the substantia nigra in patients with Parkinson's disease (PD) and controls. We found that iron significantly accumulates within neuromelanin granules of patients with PD compared to controls. Increased aluminum was found in the neuromelanin granules of 2 of 3 PD cases but in no controls. The accumulation of iron and aluminum, which are known to promote oxidant stress, may account for the selective degeneration of neuromelanin-containing neurons in PD.

AB - The Laser Microprobe Mass Analyzer (LAMMA) is a sensitive instrument for identifying and localizing trace elements in tissue samples. Using LAMMA, we have examined melanin-containing neurons of the substantia nigra in patients with Parkinson's disease (PD) and controls. We found that iron significantly accumulates within neuromelanin granules of patients with PD compared to controls. Increased aluminum was found in the neuromelanin granules of 2 of 3 PD cases but in no controls. The accumulation of iron and aluminum, which are known to promote oxidant stress, may account for the selective degeneration of neuromelanin-containing neurons in PD.

KW - Aluminum

KW - Iron

KW - Laser Microprobe Mass Analyzer

KW - Neuromelanin

KW - Oxidant stress

KW - Parkinson's disease

UR - https://www.scopus.com/pages/publications/0026746512

U2 - 10.1016/0006-8993(92)91334-B

DO - 10.1016/0006-8993(92)91334-B

M3 - Article

C2 - 1450944

AN - SCOPUS:0026746512

SN - 0006-8993

VL - 593

SP - 343

EP - 346

JO - Brain Research

JF - Brain Research

IS - 2

ER -

Neuromelanin-containing neurons of the substantia nigra accumulate iron and aluminum in Parkinson's disease: a LAMMA study

Abstract

Keywords

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