Neutralizing antibody response to booster vaccination with the 17d yellow fever vaccine

M. J. Hepburn*, M. G. Kortepeter, P. R. Pittman, E. F. Boudreau, J. A. Mangiafico, P. A. Buck, S. L. Norris, E. L. Anderson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

48 Scopus citations

Abstract

A retrospective review was conducted of yellow fever vaccination among laboratory workers receiving annual serologic assessment to determine the initial and long-term response after boosting. Patients were divided into three groups based on pre-vaccination serology: Group 1, 1:10; Group 2, 1:20-1:40 and Group 3, >1:40. The percent with ≥four-fold increase in titers after booster vaccination were: 78% (646/829, Group 1), 65% (79/121, Group 2) and 10% (8/79, Group 3) (p < 0.0001). The median times to titer failure (<1:40) were 798 days (Group 1), 3340 days (Group 2) and 7709 days (Group 3) (p < 0.0001). Pre-vaccination serology influenced the initial and long-term response to yellow fever booster vaccination.

Original languageEnglish
Pages (from-to)2843-2849
Number of pages7
JournalVaccine
Volume24
Issue number15
DOIs
StatePublished - 5 Apr 2006

Keywords

  • Booster
  • Neutralizing antibody
  • Yellow fever vaccine

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