New bigenic mouse model increases the understanding of genetic synergism in the progression of prostate cancer

David J. Polman; Douglas K. Price; William D. Figg

doi:10.1080/15384047.2015.1108498

New bigenic mouse model increases the understanding of genetic synergism in the progression of prostate cancer

David J. Polman, Douglas K. Price, William D. Figg^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

A new bigenic mouse model, engineered with the overexpression of PSGR and the knockout of PTEN, has been used to study the relationship between 2 genes and disease progression. A study in Oncogene (Rodriguez et al.) has shown that these 2 genetic polymorphisms synergistically promote the development of prostate cancer.

Original language	English
Pages (from-to)	1702-1703
Number of pages	2
Journal	Cancer Biology and Therapy
Volume	16
Issue number	12
DOIs	https://doi.org/10.1080/15384047.2015.1108498
State	Published - 2 Dec 2015
Externally published	Yes

Keywords

NF-κB pathway
PIK3/Akt pathway
PSGR
PTEN
bigenic mouse model
disease progression
genetic synergism
prostate cancer

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10.1080/15384047.2015.1108498

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title = "New bigenic mouse model increases the understanding of genetic synergism in the progression of prostate cancer",

abstract = "A new bigenic mouse model, engineered with the overexpression of PSGR and the knockout of PTEN, has been used to study the relationship between 2 genes and disease progression. A study in Oncogene (Rodriguez et al.) has shown that these 2 genetic polymorphisms synergistically promote the development of prostate cancer.",

keywords = "NF-κB pathway, PIK3/Akt pathway, PSGR, PTEN, bigenic mouse model, disease progression, genetic synergism, prostate cancer",

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New bigenic mouse model increases the understanding of genetic synergism in the progression of prostate cancer

Abstract

Keywords

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